Jasmin Lienau

TL;DR: This study suggests that there are unfavorable immune cells and factors participating in the initial healing phase and identifying beneficial aspects may lead to promising therapeutical approaches that might benefit further by eliminating the unfavorable factors.

TL;DR: An unexpected phenotype of enhanced fracture healing in RAG1−/− mice is revealed, suggesting detrimental functions of lymphocytes on fracture healing, and suggests immunomodulatory intervention strategies that maximise the regenerative and minimize the destructive effects of inflammation may lead to enhanced fracture repair.

TL;DR: Based on differential expression patterns, days 7 and 21 postoperatively were revealed to be essential time points for vascularization of the ovine fracture callus in a sheep osteotomy model.

TL;DR: This consensus report defines the basic terms "union", "delayed healing" and "non-union" in rodent animal models, and provides an overview on available models of delayed healing and non-union formation in rats and mice.

TL;DR: The study results suggest that scaffolds based on aliphatic polyesters and ceramics, which are considered biologically inactive materials, induce only limited new bone formation but could be an equivalent alternative to autologous bone when combined with a biologically active stimulus such as bone morphogenetic proteins.