Showing papers in "Journal of Orthopaedic Research in 2009"

TL;DR: The temporal release of growth factors from bone marrow aspirate, PRP, and lyophilized platelet product are compared, and their effects on tendon and ligament gene expression are measured to support in vivo investigation of PRP and PP for treatment of tendonitis and desmitis.

TL;DR: Fiber distributions were found to become more aligned under load, particularly during the low stiffness toe‐region, suggesting that fiber realignment may be partly responsible for observed nonlinear behavior.

TL;DR: Overall, the findings of this study were not significant enough to recommend the use of stem cells for the treatment of osteoarthritis represented in this model.

TL;DR: Different differences between microfracture and drilling for acute subchondral bone structure and osteocyte necrosis are revealed, and additional ongoing studies suggest these differences significantly affect long‐term cartilage repair outcome.

TL;DR: A benefit to the use of MSCs and AdIGF‐MSCs for the treatment of tendinitis is indicated, following previous work that demonstrated the value of insulin‐like growth factor‐I to stimulate cellular proliferation and tendon fiber deposition in the core lesion of Tendinitis.

TL;DR: Metal ion‐ and particle‐induced activation of the inflammasome in human macrophages provides evidence of a novel pathway of implant debris‐induced inflammation, where contact with implant debris is sensed and transduced by macrophage into a proinflammatory response.

TL;DR: It was concluded that PRP increases metabolic activity and seems to advance maturation of repair tissue over nontreated experimentally induced tendon lesions, which suggests thatPRP might be beneficial in the treatment of clinical tendon injuries.

TL;DR: The results suggest that there exists a possible direct signaling between subchondral bone and articular cartilage, and they form a functional unit with both mechanical and biochemical interactions, which may play a role in the maintenance and degeneration of the joint.

TL;DR: The results of the present study showed that this novel osteochondral scaffold is safe and easy to use, and may represent a suitable matrix to direct and coordinate the process of bone and hyaline‐like cartilage regeneration.

TL;DR: It is suggested that HIF activation is a viable approach to increase vascularity and bone formation following skeletal trauma and in a stabilized fracture model in vivo.

TL;DR: The results indicate that extremely low‐frequency PEMF stimulation may play a modulating role in hMSC osteogenesis, and provide insights on the development of PEMFs as an effective technology for regenerative medicine.

TL;DR: Mesenchymal stem cells could be isolated from various intraarticular tissues including meniscus and ligament, gene expression profiles of intraartsicular tissue MSCs closely resembled each other, and the higher expression of PRELP was characteristic of intraartic tissue M SCs.

TL;DR: The relationship between morphological variations of the bony components of the hip and resultant stresses within the soft tissues of the joint during routine daily activities were studied to find the range of morphological parameters in which stresses are minimized.

TL;DR: Structural data suggest that the main structural features that will influence meniscus repair—cellularity, vascularity, collagen structure—are similar in sheep and human but significantly different in rabbit, motivating the development of ovine meniscUS repair models.

TL;DR: The combined experimental and modeling approach used in this study provides a quantitative framework for evaluating model predictions of muscle forces in human movement and predicted muscle coordination predicted by the model was consistent with EMG measurements reported for normal walking.

TL;DR: Covering of microfractured defects with the cell‐free polymer‐based cartilage implant is suggested to be a promising treatment option for cartilage defects and improves the regeneration of articular cartilage.

TL;DR: This work outlines the effects of interstitial fluid flow, a potent biophysical signal induced by the deformation of skeletal tissue in response to applied loads, on bone cell behavior and the use of this signal in tissue engineering protocols.

TL;DR: It is concluded that dynamic compression is consistent with a notion of “healthy” loading that is able to maintain or promote matrix biosynthesis without substantially disrupting disc structural integrity.

TL;DR: It is found that the tribolayers are nanocrystalline in structure, and that they incorporate organic material stemming from the synovial fluid, which provides the basis for understanding particle release and may help in identifying new strategies to reduce MoM wear.

TL;DR: The current findings characterized the sequential, microstructural events that underlie the tendon fatigue process and indicate that tendon deformation can be used to accurately assess the progression of damage accumulation in tendons.

TL;DR: It is suggested that high levels of PGE2, which are present in tendons subjected to repetitive mechanical loading conditions in vivo as shown in this study, may result in degenerative changes of the tendon by decreasing proliferation of TSCs in tendon and also inducing differentiation of T SCs into adipocytes and osteocytes.

TL;DR: It is indicated that some subjects with patellofemoral pain exhibit abnormal weight‐bearing joint kinematics and that braces may be effective in reducing patellar maltracking in these subjects.

TL;DR: The proximal to middle part of the capsule, which includes the zona orbicularis, appears grossly and biomechanically to act as a locking ring wrapping around the neck of the femur and is a key structure for hip stability in distraction.

TL;DR: Preoperative perturbation training would help anterior cruciate ligament (ACL) deficient individuals who complain of knee instability (“non‐copers”) regain quadriceps strength and walk normally after ACL reconstruction.

TL;DR: Use of PRP alone to supplement suture repair of the ACL is ineffective in this animal model; the model had 80% power to detect a 30% improvement of biomechanical properties with PRP; thus, it is confident that a clinically meaningful effect as a result of adding PRP is unlikely.

TL;DR: Based on differential expression patterns, days 7 and 21 postoperatively were revealed to be essential time points for vascularization of the ovine fracture callus in a sheep osteotomy model.

TL;DR: It is confirmed that chondrogenesis comparable to BMMSCs can be induced from ATMSCs using a greater dose combination of growth factors, and this results lend a further support to the application of AT MSCs for cartilage tissue engineering.

TL;DR: Filtrate cells were more sensitive to seeding density during osteogenic culture but had similar capacity for chondrogenesis, and these results suggest using RIA aspirate to develop improved, clinically expeditious, cost‐effective technologies for accelerating the healing of bone and other musculoskeletal tissues.

TL;DR: The findings illustrate that mechanical cues can selectively modulate osteogenesis and chondrogenesis in vivo, and suggest a potential basis for treatment regimens for injured or diseased cartilaginous tissues.

TL;DR: The presence of differences in estimated contact stress 15 months prior to incidence suggests a biomechanical mechanism for symptomatic tibiofemoral OA and supports the ability to identify risk by subject‐specific biomechanicals modeling.