J
Jason A. Smith
Researcher at Boston University
Publications - 3
Citations - 1019
Jason A. Smith is an academic researcher from Boston University. The author has contributed to research in topics: Receptor & Toll-like receptor. The author has an hindex of 3, co-authored 3 publications receiving 996 citations. Previous affiliations of Jason A. Smith include Boston Medical Center.
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Journal ArticleDOI
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
Marco Antônio Campos,Igor C. Almeida,Osamu Takeuchi,Shizuo Akira,Eneida P. Valente,Daniela O. Procópio,Luiz R. Travassos,Jason A. Smith,Douglas T. Golenbock,Ricardo T. Gazzinelli +9 more
TL;DR: Evidence is presented that Trypanosoma cruzi-derived GPI anchors and GIPLs trigger CD25 expression on Chinese hamster ovary-K1 cells transfected with CD14 and Toll-like receptor-2 (TLR-2), but not wild-type (TLr-2-deficient) Chinese hamsters ovary cells, which may initiate host innate defense mechanisms and inflammatory response during protozoan infection.
Journal ArticleDOI
Differential Effects of a Toll-Like Receptor Antagonist on Mycobacterium tuberculosis-Induced Macrophage Responses
Terry K. Means,Bryan W. Jones,Andra B. Schromm,Beth A. Shurtleff,Jason A. Smith,Joseph Keane,Douglas T. Golenbock,Stefanie N. Vogel,Matthew J. Fenton +8 more
TL;DR: It is demonstrated that expression of a dominant negative TLR2 or TLR4 proteins in RAW 264.7 macrophages partially blocked Mtb-induced NF-κB activation, and E5531 could substantially block LPS- and Mt b-induced TNF-α production in both RAW 264,7 cells and primary human alveolar macrophage (AMφ).
Journal ArticleDOI
Novel Engagement of CD14 and Multiple Toll-Like Receptors by Group B Streptococci
Philipp Henneke,Philipp Henneke,Osamu Takeuchi,Jos A. G. van Strijp,Hilde-Kari Guttormsen,Jason A. Smith,Andra B. Schromm,Terje Espevik,Shizuo Akira,Victor Nizet,Dennis L. Kasper,Douglas T. Golenbock +11 more
TL;DR: It is suggested that CD14 and TLR2 andTLR6 function as coreceptors for secreted microbial products derived from GBS and that cell wall components of GBS are recognized by TLRs distinct from TLR1, 2, 4, or 6.