J
Jason J. Song
Researcher at Stanford University
Publications - 37
Citations - 975
Jason J. Song is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 6 publications receiving 850 citations. Previous affiliations of Jason J. Song include VA Palo Alto Healthcare System & Veterans Health Administration.
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Journal ArticleDOI
Identification of a central role for complement in osteoarthritis
Qian Wang,Andrew L. Rozelle,Christin M. Lepus,Carla R. Scanzello,Jason J. Song,D Meegan Larsen,James F. Crish,Gurkan Bebek,Gurkan Bebek,Susan Y. Ritter,Tamsin M. Lindstrom,Inyong Hwang,Heidi H. Wong,Leonardo Punzi,Angelo Encarnacion,Mehrdad Shamloo,Stuart B. Goodman,Tony Wyss-Coray,Steven R. Goldring,Nirmal K. Banda,Joshua M. Thurman,Reuben Gobezie,Mary K. Crow,V. Michael Holers,David M. Lee,David M. Lee,William H. Robinson +26 more
TL;DR: It is shown that complement, specifically, the membrane attack complex (MAC)-mediated arm of complement, is crucial to the development of arthritis in three different mouse models of osteoarthritis, and dysregulation of complement in synovial joints has a key role in the pathogenesis of arthritis.
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Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
Ricardo T. Paniagua,Orr Sharpe,Peggy P. Ho,Steven M. Chan,Anna Chang,John P. Higgins,Beren H. Tomooka,Fiona M. Thomas,Jason J. Song,Stuart B. Goodman,David Lee,Mark C. Genovese,Paul J. Utz,Lawrence Steinman,William H. Robinson +14 more
TL;DR: Imatinib-mediated inhibition of a spectrum of signal transduction pathways and the downstream pathogenic cellular responses may provide a powerful approach to treat RA and other inflammatory diseases.
Journal ArticleDOI
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis
Jason J. Song,Inyong Hwang,Kyung H. Cho,Michael Garcia,Arthur J. Kim,Tiffany H. Wang,Tamsin M. Lindstrom,Annette Lee,Toshihiko Nishimura,Lei Zhao,John Morser,Michael E. Nesheim,Stuart B. Goodman,David Lee,S. Louis Bridges,Peter K. Gregersen,Lawrence L.K. Leung,William H. Robinson +17 more
TL;DR: It is suggested that CPB plays a critical role in dampening local, C5a-mediated inflammation and represents a molecular link between inflammation and coagulation in autoimmune arthritis.
Journal ArticleDOI
Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis.
Shadi Sharif,Xiao-Yan Du,Timothy Myles,Jason J. Song,Elizabeth A. Price,David M. Lee,Stuart B. Goodman,Mariko Nagashima,John Morser,William H. Robinson,Lawrence L.K. Leung +10 more
TL;DR: The data suggest that thrombin-activatable CPB plays a central homeostatic role in RA by regulating neutrophil viability and reducing synoviocyte adhesion, and has an antiapoptotic effect on neutrophils.
Journal ArticleDOI
Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI).
TL;DR: In vitro and in vivo data support the thesis that thrombin-activatable CPB has broad anti-inflammatory properties, and show that proCPB-deficient mice displayed enhanced pulmonary inflammation and enhanced arthritis in an inflammatory arthritis model.