H
Heidi H. Wong
Researcher at Stanford University
Publications - 12
Citations - 982
Heidi H. Wong is an academic researcher from Stanford University. The author has contributed to research in topics: Immunology & Arthritis. The author has an hindex of 7, co-authored 9 publications receiving 728 citations. Previous affiliations of Heidi H. Wong include VA Palo Alto Healthcare System.
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Journal ArticleDOI
Identification of a central role for complement in osteoarthritis
Qian Wang,Andrew L. Rozelle,Christin M. Lepus,Carla R. Scanzello,Jason J. Song,D Meegan Larsen,James F. Crish,Gurkan Bebek,Gurkan Bebek,Susan Y. Ritter,Tamsin M. Lindstrom,Inyong Hwang,Heidi H. Wong,Leonardo Punzi,Angelo Encarnacion,Mehrdad Shamloo,Stuart B. Goodman,Tony Wyss-Coray,Steven R. Goldring,Nirmal K. Banda,Joshua M. Thurman,Reuben Gobezie,Mary K. Crow,V. Michael Holers,David M. Lee,David M. Lee,William H. Robinson +26 more
TL;DR: It is shown that complement, specifically, the membrane attack complex (MAC)-mediated arm of complement, is crucial to the development of arthritis in three different mouse models of osteoarthritis, and dysregulation of complement in synovial joints has a key role in the pathogenesis of arthritis.
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CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis.
Harini Raghu,Christin M. Lepus,Christin M. Lepus,Qian Wang,Qian Wang,Heidi H. Wong,Heidi H. Wong,Nithya Lingampalli,Nithya Lingampalli,Francesca Oliviero,Leonardo Punzi,Nicholas J. Giori,Stuart B. Goodman,Constance R. Chu,Constance R. Chu,Jeremy Sokolove,Jeremy Sokolove,William H. Robinson,William H. Robinson +18 more
TL;DR: Findings demonstrate that monocytes recruited via CCL2/CCR2, rather than by CCL5/ CCR5, propagate inflammation and tissue damage in OA.
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Local joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis
Dong Hyun Sohn,Christopher J. Rhodes,Kazuhiro Onuma,Xiaoyan Zhao,Orr Sharpe,Tal Gazitt,Rani Shiao,Justyna Fert-Bober,Danye Cheng,Lauren J. Lahey,Heidi H. Wong,Jennifer E. Van Eyk,William H. Robinson,Jeremy Sokolove +13 more
TL;DR: This study was undertaken to recapitulate the transition from preclinical to clinical RA and to demonstrate the capacity of local citrullination to facilitate this transition.
Journal ArticleDOI
IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis.
Qian Wang,Qian Wang,Christin M. Lepus,Christin M. Lepus,Harini Raghu,Harini Raghu,Laurent L. Reber,Mindy Tsai,Heidi H. Wong,Heidi H. Wong,Ericka von Kaeppler,Ericka von Kaeppler,Nithya Lingampalli,Nithya Lingampalli,Michelle S. Bloom,Michelle S. Bloom,Nick Hu,Nick Hu,Eileen E Elliott,Eileen E Elliott,Francesca Oliviero,Leonardo Punzi,Nicholas J. Giori,Nicholas J. Giori,Stuart B. Goodman,Constance R. Chu,Constance R. Chu,Jeremy Sokolove,Jeremy Sokolove,Yoshihiro Fukuoka,Lawrence B. Schwartz,Stephen J. Galli,William H. Robinson,William H. Robinson +33 more
TL;DR: Using genetic and pharmacologic approaches, it is shown that the IgE/FcεRI/Syk signaling axis is critical for the development of osteoarthritis and that mast cell-derived tryptase induces inflammation, chondrocyte apoptosis, and cartilage breakdown.
Journal ArticleDOI
Oral and topical boswellic acid attenuates mouse osteoarthritis.
Qian Wang,Qian Wang,X. Pan,Heidi H. Wong,Heidi H. Wong,Catriona A. Wagner,Catriona A. Wagner,Lauren J. Lahey,Lauren J. Lahey,William H. Robinson,William H. Robinson,Jeremy Sokolove,Jeremy Sokolove +12 more
TL;DR: It is suggested that boswellic acid has potential as a disease-modifying agent in OA by blocking the induction of several inflammatory mediators from OA synovial explant tissue.