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Christin M. Lepus
Researcher at Stanford University
Publications - 16
Citations - 2961
Christin M. Lepus is an academic researcher from Stanford University. The author has contributed to research in topics: Osteoarthritis & Synovial fluid. The author has an hindex of 12, co-authored 16 publications receiving 2203 citations. Previous affiliations of Christin M. Lepus include Veterans Health Administration & Brigham and Women's Hospital.
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Journal ArticleDOI
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
William H. Robinson,Christin M. Lepus,Christin M. Lepus,Qian Wang,Qian Wang,Harini Raghu,Harini Raghu,Rong Mao,Rong Mao,Tamsin M. Lindstrom,Tamsin M. Lindstrom,Jeremy Sokolove,Jeremy Sokolove +12 more
TL;DR: Osteoarthritis has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis, and increasing insight into the inflammatory underpinnings of OA holds promise for the development of new, disease-modifying therapies.
Journal ArticleDOI
Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations
TL;DR: This review will discuss a wide range of evolving data leading to the current hypotheses regarding the role of immune activation and inflammation in OA onset and progression as this is the joint most well characterized by epidemiologic, imaging, and translational studies investigating the association of inflammation with OA.
Journal ArticleDOI
Identification of a central role for complement in osteoarthritis
Qian Wang,Andrew L. Rozelle,Christin M. Lepus,Carla R. Scanzello,Jason J. Song,D Meegan Larsen,James F. Crish,Gurkan Bebek,Gurkan Bebek,Susan Y. Ritter,Tamsin M. Lindstrom,Inyong Hwang,Heidi H. Wong,Leonardo Punzi,Angelo Encarnacion,Mehrdad Shamloo,Stuart B. Goodman,Tony Wyss-Coray,Steven R. Goldring,Nirmal K. Banda,Joshua M. Thurman,Reuben Gobezie,Mary K. Crow,V. Michael Holers,David M. Lee,David M. Lee,William H. Robinson +26 more
TL;DR: It is shown that complement, specifically, the membrane attack complex (MAC)-mediated arm of complement, is crucial to the development of arthritis in three different mouse models of osteoarthritis, and dysregulation of complement in synovial joints has a key role in the pathogenesis of arthritis.
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CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis.
Harini Raghu,Christin M. Lepus,Christin M. Lepus,Qian Wang,Qian Wang,Heidi H. Wong,Heidi H. Wong,Nithya Lingampalli,Nithya Lingampalli,Francesca Oliviero,Leonardo Punzi,Nicholas J. Giori,Stuart B. Goodman,Constance R. Chu,Constance R. Chu,Jeremy Sokolove,Jeremy Sokolove,William H. Robinson,William H. Robinson +18 more
TL;DR: Findings demonstrate that monocytes recruited via CCL2/CCR2, rather than by CCL5/ CCR5, propagate inflammation and tissue damage in OA.
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Diacylglycerol Enrichment of Endoplasmic Reticulum or Lipid Droplets Recruits Perilipin 3/TIP47 during Lipid Storage and Mobilization
James R. Skinner,Trevor M. Shew,Danielle M. Schwartz,Anatoly Tzekov,Christin M. Lepus,Nada A. Abumrad,Nathan E. Wolins +6 more
TL;DR: The data suggest that these lipid droplet proteins are recruited to DG-enriched membranes thereby linking lipid coat proteins to the metabolic state of the cell.