J
Jason K. Whitmire
Researcher at University of North Carolina at Chapel Hill
Publications - 78
Citations - 6583
Jason K. Whitmire is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 41, co-authored 74 publications receiving 5887 citations. Previous affiliations of Jason K. Whitmire include Oregon Health & Science University & Scripps Research Institute.
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Journal ArticleDOI
Persistent Macrophage/Microglial Activation and Myelin Disruption after Experimental Autoimmune Encephalomyelitis in Tissue Inhibitor of Metalloproteinase-1-Deficient Mice
Stephen J. Crocker,Jason K. Whitmire,Ricardo F. Frausto,Parntip Chertboonmuang,Paul D. Soloway,J. Lindsay Whitton,Iain L. Campbell,Iain L. Campbell +7 more
TL;DR: It is suggested that induction of TIMP-1 by astrocytes during EAE in WT mice represents an inherent cytoprotective response that mitigates CNS myelin injury through the regulation of both immune cell infiltration and microglial activation.
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Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance.
Matthew A. Williams,Joyce T. Tan,Andrew B. Adams,Megan M. Durham,Nozomu Shirasugi,Jason K. Whitmire,Laurie E. Harrington,Rafi Ahmed,Thomas C. Pearson,Christian P. Larsen +9 more
TL;DR: LCMV infection prevents prolonged allograft survival following CD28/CD40 combined blockade, and LCMV prevents the induction of allospecific tolerance and mixed hematopoietic chimerism, while delay of infection for 3–4 wk posttransplant has no effect on tolerance induction.
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Direct Interferon-γ Signaling Dramatically Enhances CD4+ and CD8+ T Cell Memory
TL;DR: Direct IFN-γ signaling is not required for T cell contraction during virus infection, and it enhances, rather than suppresses, the development of virus-specific CD4+ and CD8+ T cell memory.
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GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling
Yunqi Wang,Ichiro Misumi,Ai Di Gu,T. Anthony Curtis,Lishan Su,Jason K. Whitmire,Yisong Y. Wan +6 more
TL;DR: It is found that signaling via the T cell antigen receptor (TCR) and cytokine stimulation promoted GATA-3 expression in CD8+ T cells, which controlled cell proliferation and ensured maintenance and proliferation of T cells.
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Bone Marrow Contains Virus-Specific Cytotoxic T Lymphocytes
TL;DR: After acute viral infection, virus-specific memory T cells can be found in the bone marrow compartment and are maintained for an extended period, and when adoptively transferred into an immunodeficient host, they are capable of conferring protection against chronic viral infection.