Jason M. Casolari

TL;DR: It is shown that transcriptional activation of the GAL genes results in their association with nuclear pore proteins, relocation to the nuclear periphery, and loss of RanGEF association, which indicates that the organization of the genome is coupled via transcriptional state to thenuclear transport machinery.

TL;DR: Examination of changes in nuclear organization that accompany stimulus by the mating pheromone alpha factor found that most alpha-factor-induced genes become associated with components of the nuclear envelope and the myosin-like protein Mlp1, which has been implicated in mRNA export, was further shown to exhibit RNA dependence in its association with alpha-Factor- induced genes.

TL;DR: In this paper, the authors describe three-dimensional tracking of single mRNA particles with 25-nm precision in the x and y dimensions and 50-nm accuracy in the z dimension in live budding yeast cells using a microscope with a double-helix point spread function.

TL;DR: Genome-wide location analysis shows that Hmt1 is bound to specific functional gene classes, many of which are also bound by Tho2 and other mRNA-processing factors, which suggest a model whereby HMT1 affects transcriptional elongation and, as a result, influences recruitment of RNA- processing factors.

TL;DR: Using genome-wide location analysis and transcriptional profiling in Saccharomyces cerevisiae, it is established which genes are bound and regulated by the proteasome and by Spt23 and Mga2, transcription factors activated by the Proteasome.