Jason Matthews

TL;DR: This review focuses on several of the interesting recent discoveries concerning estrogen receptors, on estrogen as a morphogen, and on the molecular mechanisms of anti-estrogen signaling.

TL;DR: The characterization of mice lacking ERalpha, or ERbeta, or both has revealed that both receptor subtypes have overlapping but also unique roles in estrogen-dependent action in vivo, and how ERalpha and ERbeta directly or indirectly affect each other's function are paramount to understanding the cellular and biological events of estrogen-mediated gene regulation in normal and diseased tissues.

TL;DR: Results demonstrate that BPA competes more effectively for binding to ERbeta, but induces ERalpha- and ERbeta-mediated gene expression with comparable efficacy, while BPA-G did not exhibit any in vitro estrogenic activity.

TL;DR: The study investigated the ability of 34 natural and synthetic chemicals to compete with [3H]17beta-estradiol (E2) for binding to bacterially expressed glutathione-S-transferase (GST)-estrogen receptors (ER) fusion proteins from five different species to demonstrate that ERs from different species exhibit differential ligand preferences and relative binding affinities for estrogenic compounds.

TL;DR: Results indicate that only selected phthalate esters exhibit weak ER-mediated activity in some in vitro assays at high concentrations but none of the eight phthalates elicited in vivo estrogenic responses based upon results obtained from uterotrophic and vaginal cornification assays.