Jasper C. Lin

TL;DR: Despite the initial hypothesis, specific Pro/Trp interactions are not essential for core formation and the Y3/P19 hydrophobic staple interaction defines the folding motif as an 18-residue unit.

TL;DR: It is found that there is residual structure due to hydrophobic collapse in the unfolded state of this small protein, and prior structuring, even with the formation of non-native rather than native contacts, may be a feature associated with fast folding events in proteins.

TL;DR: Alanine is shown to be uniquely helix-stabilizing and this stabilization is reflected in the global fold stability of the Trp-cage.

TL;DR: In this article, the orientation workspace of a 6DOF parallel manipulator is determined through boundary curves on two-dimensional cross-sections, where each boundary curve on any section consists of many segments, and each segment can be generated by solving only one constraint equation related to limited joint ranges or link interactions.

TL;DR: In this paper, 60 recombinant FVIII-C2 proteins were generated, each having a single surfaceexposed residue mutated to alanine or a conservative substitution, and the binding kinetics of these muteins to 11 monoclonal, inhibitory anti-factor VIII (FVIII)-C2 antibodies were evaluated by surface plasmon resonance.