K. Hun Mok

TL;DR: It is shown that oligomers of islet amyloid polypeptide (IAPP), a protein that formsAmyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β.

TL;DR: It is revealed that an unbound full-length p53 transactivation domain, although similar to the recently discovered group of loosely folded proteins in that it does not have tertiary structure, is nevertheless populated by an amphipathic helix and two nascent turns, suggesting that such local structures are general features of acidic transactivation domains and may represent “specificity determinants” that are important for transcriptional activity.

TL;DR: It is found that there is residual structure due to hydrophobic collapse in the unfolded state of this small protein, and prior structuring, even with the formation of non-native rather than native contacts, may be a feature associated with fast folding events in proteins.

TL;DR: The development and application of a novel rapid sample-mixing technique for real-time NMR (nuclear magnetic resonance) spectroscopy, which provides evidence for the remarkable persistence of nativelike elements of structure under conditions in which the protein is partially denatured and aggregation prone is described.

TL;DR: This review summarizes the current state of knowledge in this area based on the presentations made at the First International HAMLET Symposium in 2006.