Javier C. Angulo

TL;DR: DNA hypermethylation has emerged as a novel molecular biomarker for the evaluation of prostate cancer diagnosis and prognosis and could involve groups of genes that specifically discriminate patients with indolent and aggressive tumors.

TL;DR: It is shown that both increased ADMA and up‐regulated arginase are determinant factors in the alteration of the l‐arginine/NO pathway associated with IR in both models and also that acute treatment of arteries with arginases inhibitor or with l‐ arginine significantly alleviate endothelial dysfunction.

TL;DR: The results provide evidence for a role of D USP1 in the apoptosis of prostate cancer cells, through a mechanism involving the inhibition of p38 MAPK and NF‐κB and suggest that the ratio between DUSP1 and p65/NF‐κBs expression levels, rather than the individual expression of both molecules, is a better marker for diagnostic purposes in prostate cancer.

TL;DR: Ultrasound diagnosis of and surgical treatment for primary testicular tumors of probable testicular origin appear critical to prevent relapse because residual disease develops in a significant proportion of cases.

TL;DR: The practising clinician treating a patient with metastatic clear cell renal cell carcinoma (CCRCC) faces a difficult task of choosing the most appropriate therapeutic regimen in a rapidly developing field with recommendations derived from clinical trials.