Javier Díaz-Nido

TL;DR: The results indicate that the N-methyl-D-aspartate receptor activation leads to the dephosphorylation of the microtubule-associated protein 2 via a Ca2+/calmodulin phosphatase, probably calcineurine, which may participate in the potentiation of synaptic efficacy.

TL;DR: The decreased phosphorylation state of high molecular weight microtubule-associated protein 2 is reported during the development of cultured cerebellar granule neurons, consistent with the participation of glycogen synthase kinase-3, extracellular signal-regulated protein kinases and protein phosphatases 1 and 2A, in the regulation of micro Tubule- associated protein 2 phosphorylated within living neurons, which may be modulated by extrace cellular signals like the neurotransmitter glutamate.

TL;DR: Results suggest that MAP1B phosphorylation by CK2 may be required for the assembly of microtubules within neurites, indicating a role in the regulation of cytoskeletal functions also in mature neurons.

TL;DR: Data support the idea that secreted sema3C favors survival and neuritogenesis of cultured CGNs, and increased expression of a specific marker of neuronal cell bodies and dendrites, high molecular weight MAP2 (HMW‐MAP2).

TL;DR: The results provide the first proof‐of‐principle that hexokinase II protects against dopaminergic neurodegeneration in vivo, emphasizing the role of this enzyme in promoting neuronal survival.