J
Javier Díaz-Nido
Researcher at Spanish National Research Council
Publications - 96
Citations - 15638
Javier Díaz-Nido is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Phosphorylation & Casein kinase 2. The author has an hindex of 46, co-authored 93 publications receiving 14010 citations. Previous affiliations of Javier Díaz-Nido include Autonomous University of Madrid & Centra.
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Characterization of proteins immunologically related to brain microtubule-associated protein MAP-1B in non-neural cells
Javier Díaz-Nido,Jesús Avila +1 more
TL;DR: Two proteins bind tubulin in vitro, which suggests that they may participate in microtubule assembly in vivo; the 325Kprotein could perform such a role during the entire cell cycle, while the 220K protein could be implicated in the formation of the mitotic spindle.
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Frataxin knockdown in human astrocytes triggers cell death and the release of factors that cause neuronal toxicity
TL;DR: A detrimental effect of frataxin silencing is confirmed, not only for astrocytes, but also for neuron-glia interactions, underlining the need to take into account the role of non-cell autonomous processes in FA.
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Highly efficient and specific gene transfer to Purkinje cells in vivo using a herpes simplex virus I amplicon.
Marta Agudo,José Luis Trejo,Filip Lim,Jesús Avila,Ignacio Torres-Aleman,Javier Díaz-Nido,Francisco Wandosell +6 more
TL;DR: It is demonstrated that HSV-1 amplicon vectors can effect safe and stable transgene expression in Purkinje cells in vivo, raising the possibility of using these vectors for long-term gene therapy of human cerebellar disorders.
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Microtubule protein phosphorylation in neuroblastoma cells and neurite growth.
Javier Díaz-Nido,Rosario Armas-Portela,Isabel Correas,J. E. Dominguez,E. Montejo,Jesús Avila +5 more
TL;DR: It appears plausible that a modified sorting of casein kinase II into the nucleus and the cytoplasm may be involved in the triggering of the phosphorylation of microtubule proteins during neuroblastoma cell differentiation.
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Gene Transfer of Brain-derived Neurotrophic Factor (BDNF) Prevents Neurodegeneration Triggered by FXN Deficiency.
TL;DR: In this article, the authors used a herpesviral amplicon vector carrying a gene encoding for brain-derived neurotrophic factor (BDNF) to drive its overexpression in neuronal cells and test for its effect on FXN-deficient neurons both in culture and in the mouse cerebellum in vivo.