J
Javier Díaz-Nido
Researcher at Spanish National Research Council
Publications - 96
Citations - 15638
Javier Díaz-Nido is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Phosphorylation & Casein kinase 2. The author has an hindex of 46, co-authored 93 publications receiving 14010 citations. Previous affiliations of Javier Díaz-Nido include Autonomous University of Madrid & Centra.
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Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells.
TL;DR: It is reported that this type of MAP1B phosphorylation is practically abolished in proliferating neuroblastoma cells that are treated with chemical inhibitors of cyclin‐dependent kinases.
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Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3.
TL;DR: It is demonstrated that chronic inhibition of GSK-3 reprograms the metabolism of neuronal cells, leading to an enhancement of glycolysis, and HKII overexpression is sufficient to protect against rotenone-induced cell death, and mitochondrial HKII is a promoter of neuronal survival under the regulation of G SK-3.
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Localization of differentially phosphorylated isoforms of microtubule-associated protein 1B in cultured rat hippocampal neurons
TL;DR: The results are compatible with a role for the mode I phosphorylation of MAP1B in supporting a rapid axonal-specific growth mechanism and a more general role in controlling axonal and dendritic growth and remodeling.
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Functional Recovery in a Friedreich's Ataxia Mouse Model by Frataxin Gene Transfer Using an HSV-1 Amplicon Vector
Filip Lim,Gloria M Palomo,Christina Mauritz,Alfredo Giménez-Cassina,Belén Illana,Francisco Wandosell,Javier Díaz-Nido +6 more
TL;DR: It is shown that frataxin expression can be eliminated in neurons from these loxP[frda] mice by infection with CRE-expressing herpes simplex virus type 1 (HSV-1) amplicon vectors, the first proof of principle of recovery of neurological function by a therapeutic agent aimed at correcting fr ataxin deficiency.
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Low-Dose Curcumin Stimulates Proliferation, Migration and Phagocytic Activity of Olfactory Ensheathing Cells
Johana Tello Velasquez,Michelle Watts,Michael Todorovic,Lynn Leo Nazareth,Erika Pastrana,Javier Díaz-Nido,Filip Lim,Jenny Ekberg,Ronald J. Quinn,James Anthony St John +9 more
TL;DR: Results constitute the first evidence that low-dose curcumin can modulate the behaviour of olfactory glia into a phenotype potentially more favourable for neural repair and thereby improve the therapeutic use of OECs for Neural repair therapies.