J
Javier Mestas
Researcher at University of California, Irvine
Publications - 15
Citations - 4622
Javier Mestas is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Angiogenesis & CXC chemokine receptors. The author has an hindex of 11, co-authored 13 publications receiving 4154 citations. Previous affiliations of Javier Mestas include University of California, Los Angeles.
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Journal ArticleDOI
Of mice and not men: differences between mouse and human immunology
TL;DR: Known discrepancies in both innate and adaptive immunity are outlined, including balance of leukocyte subsets, defensins, Toll receptors, inducible NO synthase, the NK inhibitory receptor families Ly49 and KIR, FcR, Ig subsets andChemokine and chemokine receptor expression.
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Cancer CXC chemokine networks and tumour angiogenesis.
Robert M. Strieter,Marie D. Burdick,Javier Mestas,Brigitte N. Gomperts,Michael P. Keane,John A. Belperio +5 more
TL;DR: Members of the CXC chemokine family, such as platelet factor-4 (PF4; CXCL4) and interferon-inducible CXS chemokines are potent inhibitors of angiogenesis, and use CXCR3 on endothelium to mediate their angiostatic activity.
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Epidermal Growth Factor and Hypoxia-induced Expression of CXC Chemokine Receptor 4 on Non-small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mammalian Target of Rapamycin Signaling Pathway and Activation of Hypoxia Inducible Factor-1α *
Roderick J. Phillips,Javier Mestas,Mehrnaz Gharaee-Kermani,Marie D. Burdick,Antonio Sica,John A. Belperio,Michael P. Keane,Robert M. Strieter +7 more
TL;DR: A combination of low oxygen tension and overexpression of EGFR within the primary tumor of NSCLC may provide the microenvironmental signals necessary to upregulate CXCR4 expression and promote metastasis.
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Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
Judong Pan,Javier Mestas,Marie D. Burdick,Roderick J. Phillips,George Thomas,Karen L. Reckamp,John A. Belperio,Robert M. Strieter +7 more
TL;DR: The data suggest that the CXCL12/CXCR4 biological axis plays an important role in regulating the organ-specific metastasis of RCC.
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Identification of Endothelial Cell Genes Expressed in an in Vitro Model of Angiogenesis: Induction of ESM-1, βig-h3, and NrCAM☆
Mark Aitkenhead,Shur-Jen Wang,Martin N. Nakatsu,Javier Mestas,Cheryl Heard,Christopher C.W. Hughes +5 more
TL;DR: The PCR-based subtractive hybridization method, representational difference analysis, is used to identify genes upregulated in endothelial cells (EC) forming tubes in 3D collagen gels, compared to migrating and proliferating cells in 2D cultures, expanding the suite of genes implicated in vascular remodeling and angiogenesis.