M
Mehrnaz Gharaee-Kermani
Researcher at University of Michigan
Publications - 67
Citations - 4292
Mehrnaz Gharaee-Kermani is an academic researcher from University of Michigan. The author has contributed to research in topics: Pulmonary fibrosis & Fibrosis. The author has an hindex of 30, co-authored 48 publications receiving 3944 citations. Previous affiliations of Mehrnaz Gharaee-Kermani include University of Massachusetts Boston.
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Journal ArticleDOI
Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin.
James Varani,Roscoe L. Warner,Mehrnaz Gharaee-Kermani,Sem H. Phan,Sewon Kang,Jin Ho Chung,Zeng Quan Wang,Subhash C. Datta,Gary J. Fisher,John J. Voorhees +9 more
TL;DR: It is indicated that naturally aged, sun-protected skin and photoaged skin share important molecular features including connective tissue damage, elevated matrix metalloproteinase levels, and reduced collagen production.
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Costimulation of Fibroblast Collagen and Transforming Growth Factor β1 Gene Expression by Monocyte Chemoattractant Protein-1 via Specific Receptors
TL;DR: The results taken together suggest that MCP-1 stimulates fibroblast collagen expression via specific receptors and endogenous up-regulation of TGFβ expression, which then results in autocrine and/or juxtacrine stimulation of collagen gene expression.
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Epidermal Growth Factor and Hypoxia-induced Expression of CXC Chemokine Receptor 4 on Non-small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mammalian Target of Rapamycin Signaling Pathway and Activation of Hypoxia Inducible Factor-1α *
Roderick J. Phillips,Javier Mestas,Mehrnaz Gharaee-Kermani,Marie D. Burdick,Antonio Sica,John A. Belperio,Michael P. Keane,Robert M. Strieter +7 more
TL;DR: A combination of low oxygen tension and overexpression of EGFR within the primary tumor of NSCLC may provide the microenvironmental signals necessary to upregulate CXCR4 expression and promote metastasis.
Journal Article
Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis.
TL;DR: Results show that cells with the myofibroblast phenotype are more abundant in fibrotic lung, and that these cells possess greater contractile capacity in vitro at least partly by virtue of their enhanced endogenous TGF-beta 1 gene expression.
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Role of Cytokines and Cytokine Therapy in Wound Healing and Fibrotic Diseases
TL;DR: Progress in understanding the mechanisms underlying the pathogenesis of fibrosis leads us to expect that inhibitors of pro-fibrogenic cytokines and growth factors may be useful as novel therapeutic agents in controlling undesirable fibrosis.