Jay M. Weiss

TL;DR: This work presents a meta-anatomy of the adrenal gland and its role in the development and management of disease and urges further investigation into the role of “cell reprograming” and “reconcretization” in the course of disease progression.

TL;DR: The presence of bioactive interleukin-1 in various brain regions after either intraperitoneal or intraventricular injection of lipopolysaccharide was studied, indicating that it is found in the extracellular fluid of many brain regions following an appropriate stimulus in the periphery as well as in the brain.

TL;DR: It is proposed that GAL release in VTA inhibits the activity of dopaminergic cell bodies in this region whose axons project to forebrain, resulting in two of the principal symptoms seen in depression, decreased motor activation and decreased appreciation of pleasurable stimuli.

TL;DR: It is suggested that, at least in rats, the capacity of stress-inducing or aversive stimuli to activate LC neurons does not potentiate anxiety under environmental conditions that elicit this response, but, rather, the increased activity of the LC/dorsal noradrenergic system under such conditions may exert a counterbalancing, antianxiety influence.

TL;DR: Results indicate a link from brain to peripheral immune responses by means of action of a cytokine acting in the brain, and show that the effects of central IL-1 on peripheral cellular immune responses were, at least in part, independent of the stimulatory effect of IL- 1 on secretion of adrenal hormones.