Jay S. Prendergast

TL;DR: Comparative studies with human alpha, beta, and gamma interferons indicated that sensitivity to hTNF and interferon can be distinguished, and combined treatment with hT NF and alpha or gamma interFERon resulted in a synergistic cytotoxic effect.

TL;DR: The genetic ablation of Akt1 on an apolipoprotein E knockout background (ApoE(-/-)Akt1(-/-)) increases aortic lesion expansion and promotes coronary atherosclerosis in mice and provides a new model for studying the mechanisms of acute coronary syndrome in humans.

TL;DR: It is shown that delivery of Cav-1 amino acids 82-101 (Cav) fused to an internalization sequence from Antennapedia (AP) blocks NO release in vitro and inflammation and tumor angiogenesis in vivo.

TL;DR: In this paper, the authors identify a previously uncharacterized Nogo-B receptor specific for the amino terminus of Nogo isoforms and show that this receptor localizes with the ligand Nogo B during VEGF and wound healing angiogenesis in vivo.

TL;DR: It is found that endothelial-specific overexpression of Cav-1 enhanced the progression of atherosclerosis in mice and reduced endothelial cell proliferation, migration, and nitric oxide production in vitro and increased expression of vascular cell adhesion molecule-1 in vivo.