F
Fenghua Hu
Researcher at Cornell University
Publications - 59
Citations - 4593
Fenghua Hu is an academic researcher from Cornell University. The author has contributed to research in topics: Frontotemporal lobar degeneration & Lysosome. The author has an hindex of 28, co-authored 46 publications receiving 3969 citations. Previous affiliations of Fenghua Hu include Baylor College of Medicine & Howard Hughes Medical Institute.
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Journal ArticleDOI
Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms
Yolanda Sanchez,Jeff Bachant,Hong Wang,Fenghua Hu,Dou Liu,Michael T. Tetzlaff,Michael T. Tetzlaff,Stephen J. Elledge,Stephen J. Elledge +8 more
TL;DR: A model in which Chk1 and Rad53 function in parallel through Pds1 and Cdc5, respectively, to prevent anaphase entry and mitotic exit after DNA damage is supported, providing a possible explanation for the role of CDC5 in DNA damage checkpoint adaptation.
Journal ArticleDOI
Mrc1 transduces signals of DNA replication stress to activate Rad53.
Annette A. Alcasabas,Alexander J. Osborn,Jeff Bachant,Jeff Bachant,Fenghua Hu,Petra J. H. Werler,Kristine Bousset,Kanji Furuya,John F.X. Diffley,Antony M. Carr,Stephen J. Elledge +10 more
TL;DR: Mrc1 mutants are sensitive to hydroxyurea and have a checkpoint defect similar to rad53 and cds1 mutants, which may be the replicative counterpart of Rad9 and Crb2, which are required for activating ScRad53 and Chk1 in response to DNA damage.
Journal ArticleDOI
Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
Fenghua Hu,Thihan Padukkavidana,Christian Bjerggaard Vaegter,Owen A. Brady,Yanqiu Zheng,Ian R. A. Mackenzie,Howard Feldman,Anders Nykjaer,Stephen M. Strittmatter +8 more
TL;DR: The 50% PGRN decrease causative in FTLD-TDP cases is mimicked in GRN+/⁻ mice, and is fully normalized by Sort1 ablation, suggesting Sortilin-mediated PGRn endocytosis is likely to play a central role in FT LD-T DP pathophysiology.
Journal ArticleDOI
Regulation of the Bub2/Bfa1 GAP Complex by Cdc5 and Cell Cycle Checkpoints
TL;DR: It is found that Polo/Cdc5 kinase acts upstream of Bfa1/Bub2 in the mitotic exit network and acts to antagonize Bfa 1 function to promote mitoticExit.
Journal ArticleDOI
The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway
Peter M. Sullivan,Xiaolai Zhou,Adam M. Robins,Daniel H. Paushter,Dongsung Kim,Marcus B. Smolka,Fenghua Hu +6 more
TL;DR: This study elucidates potential physiological functions of C9orf72 and disease mechanisms of ALS/FTLD and demonstrates that C 9orf72/SMCR8/WDR41 associates with the FIP200/Ulk1 complex, which is essential for autophagy initiation.