J
Jayaram Chandrashekar
Researcher at Howard Hughes Medical Institute
Publications - 42
Citations - 13449
Jayaram Chandrashekar is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Taste receptor & Taste. The author has an hindex of 24, co-authored 40 publications receiving 11984 citations. Previous affiliations of Jayaram Chandrashekar include University of California, San Diego & National Institutes of Health.
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Mammalian sweet taste receptors
Charles S. Zuker,Nicholas J. P. Ryba,Gregory A. Nelson,Mark A. Hoon,Jayaram Chandrashekar,Yifeng Zhang +5 more
TL;DR: A detailed analysis of the patterns of expression of T1Rs and T2Rs is presented, thus providing a view of the representation of sweet and bitter taste at the periphery.
Journal ArticleDOI
An amino-acid taste receptor
Greg Nelson,Jayaram Chandrashekar,Mark A. Hoon,Luxin Feng,Grace Zhao,Nicholas J. P. Ryba,Charles S. Zuker +6 more
TL;DR: This work identifies and characterize a mammalian amino-acid taste receptor and shows that sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses.
Journal ArticleDOI
The receptors and cells for mammalian taste
TL;DR: The emerging picture of taste coding at the periphery is one of elegant simplicity, it is now clear that distinct cell types expressing unique receptors are tuned to detect each of the five basic tastes.
Journal ArticleDOI
T2Rs function as bitter taste receptors.
Jayaram Chandrashekar,Ken Mueller,Mark A. Hoon,Elliot Adler,Luxin Feng,Wei Guo,Charles S. Zuker,Nicholas J. P. Ryba +7 more
TL;DR: A heterologous expression system is used to show that specific T2Rs function as bitter taste receptors, and these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds.
Journal ArticleDOI
A novel family of mammalian taste receptors.
Elliot Adler,Mark A. Hoon,Ken Mueller,Jayaram Chandrashekar,Nicholas J. P. Ryba,Charles S. Zuker +5 more
TL;DR: It is demonstrated that T2Rs couple to gustducin in vitro, and respond to bitter tastants in a functional expression assay, implying that they function as gust Ducin-linked receptors.