Jayne Moquet

TL;DR: The biological meaning and significance of DNA damage foci is reviewed, looking specifically at a range of different settings in which such markers of DNAdamage and repair are being studied and interpreted.

TL;DR: Analysis of the dose response for 250 kVp X-rays indicates that although the Y = αD + βD 2 model fits the data, the relationship does not correspond to that for total aberration induction as might have been expected, and indicates that simple incorporation of acentric chromosome fragments into micronuclei may not wholly account for the phenomenon.

TL;DR: Preliminary dose estimates by chromosomal analysis can be made rapidly in order to supplement early triage of radiation casualties based on clinical signs and confirmation of clinical triage can generally be obtained from scoring 20 metaphases per subject.

TL;DR: The DCA has been confirmed as the gold standard biodosimetry method, but in situations where speed and throughput are more important than ultimate accuracy, the emerging rapid molecular assays have the potential to become useful triage tools.

TL;DR: The technique works and a lifetime dose to the bone marrow from low-linear energy transfer radiation of 0.5 Gy above normal background levels can be measured for any individual.