J
Jean-Baptiste Vignalou
Researcher at University of Paris
Publications - 12
Citations - 587
Jean-Baptiste Vignalou is an academic researcher from University of Paris. The author has contributed to research in topics: Prasugrel & Acute coronary syndrome. The author has an hindex of 10, co-authored 12 publications receiving 543 citations. Previous affiliations of Jean-Baptiste Vignalou include French Institute of Health and Medical Research & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis.
Guillaume Cayla,Jean-Sébastien Hulot,Stephen A. O’Connor,Atul Pathak,Stuart A. Scott,Yves Gruel,Johanne Silvain,Jean-Baptiste Vignalou,Yves Huerre,Axel de la Briolle,Frédérick Allanic,Farzin Beygui,Olivier Barthelemy,Gilles Montalescot,Jean-Philippe Collet +14 more
TL;DR: This case-control study identified 3 genes (CYP2C19, ABCB1, and ITGB3) and 2 clopidogrel-related factors (loading dose and proton pump inhibitors) that were independently associated with early stent thrombosis.
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High doses of clopidogrel to overcome genetic resistance: the randomized crossover CLOVIS-2 (Clopidogrel and Response Variability Investigation Study 2).
Jean-Philippe Collet,Jean-Sébastien Hulot,Ghalia Anzaha,Ana Pena,Thomas Chastre,Claire Caron,Johanne Silvain,Guillaume Cayla,Anne Bellemain-Appaix,Jean-Baptiste Vignalou,Sophie Galier,Olivier Barthelemy,Farzin Beygui,Vanessa Gallois,Gilles Montalescot,Clovis Investigators +15 more
TL;DR: There was a significant correlation between PK and PD responses irrespective of the LD and a similar pattern was observed for the active metabolite AUC(0-6) according to carriage of CYP2C19*2 for both LDs.
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Impact of red blood cell transfusion on platelet aggregation and inflammatory response in anemic coronary and noncoronary patients: the TRANSFUSION-2 study (impact of transfusion of red blood cell on platelet activation and aggregation studied with flow cytometry use and light transmission aggregometry).
Johanne Silvain,Jérémie Abtan,Mathieu Kerneis,Rejane Martin,Jonathan Finzi,Jean-Baptiste Vignalou,Olivier Barthelemy,Stephen A. O’Connor,Charles-Edouard Luyt,Nicolas Bréchot,Anne Mercadier,Delphine Brugier,Sophie Galier,Jean-Philippe Collet,Jean Chastre,Gilles Montalescot +15 more
TL;DR: In this article, the authors sought to determine whether red blood cell (RBC) transfusion increases in vivo platelet aggregation and inflammation in coronary and non-coronary patients.
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Switching Acute Coronary Syndrome Patients From Prasugrel to Clopidogrel
Mathieu Kerneis,Johanne Silvain,Jérémie Abtan,Guillaume Cayla,Guillaume Cayla,Stephen A. O’Connor,Olivier Barthelemy,Jean-Baptiste Vignalou,Farzin Beygui,Delphine Brugier,Rejane Martin,Jean-Philippe Collet,Gilles Montalescot +12 more
TL;DR: Early switching from prasugrel 10 mg to clopidogrel 75 mg reduces the number of patients with low on-treatment platelet reactivity and minor bleeding events but unmasks a group of nonresponders to clobodanogrel with unknown consequences on clinical outcomes.
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Impact of red blood cell transfusion on platelet activation and aggregation in healthy volunteers: results of the TRANSFUSION study
Johanne Silvain,Ana Pena,Guillaume Cayla,David Brieger,Anne Bellemain-Appaix,Thomas Chastre,Jean-Baptiste Vignalou,Farzin Beygui,Olivier Barthelemy,Jean-Philippe Collet,Gilles Montalescot +10 more
TL;DR: Red blood cell transfusion increases platelet activation and aggregation in vitro in healthy volunteers and this effect might be mediated through the P2Y(12) activation pathway.