J
Jean-François Delfraissy
Researcher at French Institute of Health and Medical Research
Publications - 292
Citations - 16835
Jean-François Delfraissy is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Viral load & Acquired immunodeficiency syndrome (AIDS). The author has an hindex of 66, co-authored 283 publications receiving 15991 citations. Previous affiliations of Jean-François Delfraissy include University of Paris-Sud & GlaxoSmithKline.
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Journal ArticleDOI
Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues
Stéphane Blanche,Marc Tardieu,Pierre Rustin,A. Slama,Béatrice Barret,Ghislaine Firtion,Nicole Ciraru-Vigneron,Catherine Lacroix,Christine Rouzioux,Laurent Mandelbrot,Isabelle Desguerre,Agnès Rötig,Marie-Jeanne Mayaux,Jean-François Delfraissy +13 more
TL;DR: The hypothesis of a link between mitochondrial dysfunction and the perinatal administration of prophylactic nucleoside analogues supported, current recommendations for zidovudine monotherapy should however be maintained.
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HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype.
Asier Sáez-Cirión,Christine Lacabaratz,Olivier Lambotte,Pierre Versmisse,Alejandra Urrutia,Faroudy Boufassa,Françoise Barré-Sinoussi,Jean-François Delfraissy,Martine Sinet,Gianfranco Pancino,Alain Venet +10 more
TL;DR: Although CD4+ T cells from HIC were fully susceptible to HIV-1 superinfection, their CD8- T cells effectively suppressed HIV- 1 infection, indicating an HLA-restricted cytotoxic mechanism that could account for the control of viral replication in HIC.
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Earlier versus Later Start of Antiretroviral Therapy in HIV-Infected Adults with Tuberculosis
François-Xavier Blanc,Thim Sok,Didier Laureillard,Laurence Borand,Claire Rekacewicz,Eric Nerrienet,Yoann Madec,Olivier Marcy,Sarin Chan,Narom Prak,Chindamony Kim,Khemarin Kim Lak,Chanroeurn Hak,Bunnet Dim,Chhun Im Sin,Sath Sun,Bertrand Guillard,Borann Sar,Sirenda Vong,Marcelo Fernandez,Larry A. Fox,Jean-François Delfraissy,Anne E. Goldfeld +22 more
TL;DR: Starting antiretroviral therapy 2 weeks after the start of tuberculosis treatment significantly improved survival among HIV-infected adults with CD4+ T-cell counts of 200 per cubic millimeter or lower.
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Prevalence of HIV-related pulmonary arterial hypertension in the current antiretroviral therapy era.
Olivier Sitbon,Caroline Lascoux-Combe,Jean-François Delfraissy,Patrick Yeni,François Raffi,Dominique De Zuttere,Virginie Gressin,Pierre Clerson,Daniel Sereni,Gérald Simonneau +9 more
TL;DR: Given the current good long-term prognosis of patients with HIV, the severity of PAH in HIV-infected patients, and the absence of predictive factors, careful screening for PAH is warranted for patients with unexplained dyspnea.
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Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1
Laurent Mandelbrot,Aline Landreau-Mascaro,Claire Rekacewicz,Alain Berrebi,Jean Louis Bénifla,Marianne Burgard,Eric Lachassine,Béatrice Barret,Marie-Laure Chaix,André Bongain,Nicole Ciraru-Vigneron,Catherine Crenn-Hebert,Jean-François Delfraissy,Christine Rouzioux,Marie-Jeanne Mayaux,Stéphane Blanche +15 more
TL;DR: Lamivudine-zidovudine prophylaxis therapy may be effective in preventing maternal-infant HIV transmission, however, severe adverse effects and emergence of resistance to lamivUDine occurred.