Marie-Jeanne Mayaux

TL;DR: The hypothesis of a link between mitochondrial dysfunction and the perinatal administration of prophylactic nucleoside analogues supported, current recommendations for zidovudine monotherapy should however be maintained.

TL;DR: Lamivudine-zidovudine prophylaxis therapy may be effective in preventing maternal-infant HIV transmission, however, severe adverse effects and emergence of resistance to lamivUDine occurred.

TL;DR: Children exposed to nucleoside analogues during the perinatal period are at risk of a neurological syndrome associated with persistent mitochondrial dysfunction, close similarities in clinical, neuroradiological and histological findings strongly suggest a common pathological process in all these 26 children.

TL;DR: The authors conclude that mother-to-child HIV-1 transmission appears to occur late in pregnancy or at delivery, and support the view that HIV infection can be diagnosed during the first 3 months of life.

TL;DR: There is an improvement in semen characteristics up to 25 years of age, followed by a leveling off and a subsequent decrease, and the variation, although small, is highly significant for the morphologic characteristics and prefreeze and postthaw motility.