J
Jean-François Schmouth
Researcher at Montreal Neurological Institute and Hospital
Publications - 5
Citations - 49
Jean-François Schmouth is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Essential tremor & Gene. The author has an hindex of 2, co-authored 4 publications receiving 44 citations. Previous affiliations of Jean-François Schmouth include McGill University & Université de Montréal.
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Journal ArticleDOI
Genetics of essential tremor: from phenotype to genes, insights from both human and mouse studies.
Jean-François Schmouth,Jean-François Schmouth,Patrick A. Dion,Patrick A. Dion,Guy A. Rouleau +4 more
TL;DR: It is argued that better communication between researchers of different fields is warranted to define the biological origin of ET in the hope of leading to the development of better treatments, and to reconcile evidence from both fields and leading to novel clues guiding future studies.
Journal ArticleDOI
Teneurin transmembrane protein 4 is not a cause for essential tremor in a Canadian population.
Gabrielle Houle,Jean-François Schmouth,Jean-François Schmouth,Claire S. Leblond,Amirthagowri Ambalavanan,Dan Spiegelman,Sandra B. Laurent,Cynthia V. Bourassa,Michel Panisset,Sylvain Chouinard,Nicolas Dupré,Carles Vilariño-Güell,Alex Rajput,Patrick A. Dion,Patrick A. Dion,Guy A. Rouleau,Guy A. Rouleau +16 more
TL;DR: The aim of this study was to determine the frequency and spectrum of variations in teneurin transmembrane protein 4 in a cohort of Canadian essential tremor cases.
Journal ArticleDOI
No rare deleterious variants from STK32B, PPARGC1A, and CTNNA3 are associated with essential tremor.
Gabrielle Houle,Amirthagowri Ambalavanan,Jean-François Schmouth,Claire S. Leblond,Dan Spiegelman,Sandra B. Laurent,Cynthia V. Bourassa,Celene Grayson,Michel Panisset,Sylvain Chouinard,Nicolas Dupré,Carles Vilariño-Güell,Alex Rajput,Simon Girard,Patrick A. Dion,Guy A. Rouleau +15 more
TL;DR: No rare exonic variants further validated one of these genes as a risk factor for ET, but the genetic heterogeneity of ET is nonetheless challenging for the validation of risk factors, and larger cohorts of cases should help to overcome this task.
Journal ArticleDOI
Absence of Mutation Enrichment for Genes Phylogenetically Conserved in the Olivocerebellar Motor Circuitry in a Cohort of Canadian Essential Tremor Cases.
Jean-François Schmouth,Jean-François Schmouth,Gabrielle Houle,Gabrielle Houle,Amirthagowri Ambalavanan,Amirthagowri Ambalavanan,Claire S. Leblond,Claire S. Leblond,Dan Spiegelman,Sandra B. Laurent,Cynthia V. Bourassa,Michel Panisset,Sylvain Chouinard,Nicolas Dupré,Carles Vilariño-Güell,Alex Rajput,Patrick A. Dion,Patrick A. Dion,Guy A. Rouleau,Guy A. Rouleau +19 more
TL;DR: The results from this list of 11 candidate genes do not support an association for Essential Tremor in a cohort of Canadian cases, and the heterogenic nature of ET and modest size of the cohort used in this study are two confounding factors that could explain these results.
Journal ArticleDOI
Introduction of loxP sites by electroporation in the mouse genome; a simple approach for conditional allele generation in complex targeting loci
TL;DR: In this paper , a modification of this sequential electroporation procedure was described, which demonstrated the production of conditional allele mouse models for eight different genes via one of two possible strategies: either by consecutive sequenceto-regeneration (strategy A) or non-consecutive sequential electrophoration (strategies B and C).