A
Amirthagowri Ambalavanan
Researcher at McGill University
Publications - 27
Citations - 1094
Amirthagowri Ambalavanan is an academic researcher from McGill University. The author has contributed to research in topics: Exome sequencing & Genome-wide association study. The author has an hindex of 14, co-authored 25 publications receiving 876 citations. Previous affiliations of Amirthagowri Ambalavanan include Université de Montréal & Montreal Neurological Institute and Hospital.
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Journal ArticleDOI
De Novo Mutations in Moderate or Severe Intellectual Disability
Fadi F. Hamdan,Myriam Srour,Jose-Mario Capo-Chichi,Hussein Daoud,Christina Nassif,Lysanne Patry,Christine Massicotte,Amirthagowri Ambalavanan,Dan Spiegelman,Ousmane Diallo,Edouard Henrion,Alexandre Dionne-Laporte,Anne Fougerat,Alexey V. Pshezhetsky,Sunita Venkateswaran,Guy A. Rouleau,Jacques L. Michaud +16 more
TL;DR: It is concluded that DNMs represent a major cause of moderate or severe ID.
Journal ArticleDOI
Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder.
Lea Thaler,Lise Gauvin,Ridha Joober,Patricia Groleau,Rosherrie de Guzman,Amirthagowri Ambalavanan,Mimi Israel,Samantha Wilson,Howard Steiger,Howard Steiger +9 more
TL;DR: The findings suggest that BN, especially when co-occurring with childhood abuse or BPD, is associated with a propensity towards elevated methylation at specific BDNF promoter region sites, implying that hypermethylation of the BDNF gene may be related to eating disorder status, developmental stress exposure, and comorbid psychopathology.
Journal ArticleDOI
SMPD1 mutations, activity, and α-synuclein accumulation in Parkinson's disease
Roy N. Alcalay,Victoria Mallett,Benoît Vanderperre,Omid Tavassoly,Yves Dauvilliers,Richard Y.J. Wu,Richard Y.J. Wu,Jennifer A. Ruskey,Jennifer A. Ruskey,Claire S. Leblond,Claire S. Leblond,Amirthagowri Ambalavanan,Amirthagowri Ambalavanan,Sandra B. Laurent,Sandra B. Laurent,Dan Spiegelman,Dan Spiegelman,Alexandre Dionne-Laporte,Alexandre Dionne-Laporte,Christopher Liong,Oren A. Levy,Stanley Fahn,Cheryl Waters,Sheng-Han Kuo,Wendy K. Chung,Blair Ford,Karen Marder,Un Jung Kang,Sharon Hassin-Baer,Sharon Hassin-Baer,Lior Greenbaum,Lior Greenbaum,Jean-François Trempe,Pavlina Wolf,Petra Oliva,Xiaokui Kate Zhang,Lorraine N. Clark,Mélanie Langlois,Patrick A. Dion,Patrick A. Dion,Edward A. Fon,Nicolas Dupré,Guy A. Rouleau,Guy A. Rouleau,Ziv Gan-Or,Ziv Gan-Or +45 more
TL;DR: The objective of this study was to further investigate the role of SMPD1 mutations in PD.
Journal ArticleDOI
De novo variants in sporadic cases of childhood onset schizophrenia.
Amirthagowri Ambalavanan,Simon Girard,Kwangmi Ahn,Sirui Zhou,Alexandre Dionne-Laporte,Dan Spiegelman,Cynthia V. Bourassa,Julie Gauthier,Fadi F. Hamdan,Lan Xiong,Patrick A. Dion,Ridha Joober,Ridha Joober,Judith L. Rapoport,Guy A. Rouleau,Guy A. Rouleau +15 more
TL;DR: SeZ6, RYR2, GPR153, GTF2IRD1, TTBK1 and ITGA6 have been previously linked to neuronal function or to psychiatric disorders, and thus may be considered as COS candidate genes.
Journal ArticleDOI
GBA p.T369M substitution in Parkinson disease: Polymorphism or association? A meta-analysis.
Victoria Mallett,Jay P. Ross,Roy N. Alcalay,Amirthagowri Ambalavanan,Ellen Sidransky,Patrick A. Dion,Guy A. Rouleau,Ziv Gan-Or +7 more
TL;DR: Clinical trials on GBA-associated PD are ongoing, and because treatment specifically targeting GBA is likely to be available in the future, it is important to determine whether the GBA p.T369M substitution is associated with PD.