J
Jean Giudicelli
Researcher at University of Nice Sophia Antipolis
Publications - 13
Citations - 701
Jean Giudicelli is an academic researcher from University of Nice Sophia Antipolis. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 9, co-authored 13 publications receiving 662 citations. Previous affiliations of Jean Giudicelli include Centre Hospitalier Universitaire de Nice & French Institute of Health and Medical Research.
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Journal ArticleDOI
Methylglyoxal Impairs the Insulin Signaling Pathways Independently of the Formation of Intracellular Reactive Oxygen Species
Audrey Riboulet-Chavey,Anne Pierron,Isabelle Durand,Joseph Murdaca,Jean Giudicelli,Emmanuel Van Obberghen +5 more
TL;DR: The data suggest that an increase in intracellular methylglyoxal content hampers a key molecule, thereby leading to inhibition of insulin-induced signaling in L6 muscle cells, and may contribute to the pathophysiology of diabetes in general.
Journal ArticleDOI
Rat liver injury following normothermic ischemia is prevented by a phosphinic matrix metalloproteinase inhibitor
R. Cursio,Bernard Mari,Krystel Louis,Philippe Rostagno,Marie-Christine Saint-Paul,Jean Giudicelli,Virginie Bottero,Patrick Anglard,Athanasios Yiotakis,Vincent Dive,Jean Gugenheim,Patrick Auberger +11 more
TL;DR: Inhibition of MMP activity was shown to significantly decrease liver injury in ischemic/reperfused liver tissue as assessed by histological studies and serum hepatic enzyme levels, suggesting that MMP inhibitors may be of clinical relevance in liver‐associated isChemic diseases or after liver transplantation.
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Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E
Francesca Fiory,Angela Lombardi,Claudia Miele,Jean Giudicelli,Jean Giudicelli,Francesco Beguinot,E Van Obberghen,E Van Obberghen +7 more
TL;DR: MGO participates not only in the pathogenesis of the debilitating complications of type 2 diabetes, but also in worsening of the diabetic state by favouring beta cell failure.
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The severity of liver fibrosis is associated with high leptin levels in chronic hepatitis C.
Thierry Piche,F. Vandenbos,A. Abakar-Mahamat,Geoffroy Vanbiervliet,E. M. Barjoan,Gustavo Calle,Jean Giudicelli,B. Ferrua,C. Laffont,Sylvia Benzaken,Albert Tran +10 more
TL;DR: In patients with CHC and higher BMI and glycaemia levels, the severity of liver fibrosis is associated with serum leptin, and TNF‐α is a putative candidate involved in the mechanism.
Journal ArticleDOI
Fatigue is associated with high circulating leptin levels in chronic hepatitis C
Thierry Piche,E. Gelsi,Stéphane M. Schneider,Xavier Hébuterne,Jean Giudicelli,B. Ferrua,C. Laffont,Sylvia Benzaken,Patrick Hastier,M L Montoya,F. Longo,Patrick Rampal,Albert Tran +12 more
TL;DR: Fatigue is present in CHC patients and is more pronounced in females and the FIS questionnaire is clinically relevant and may be useful for future therapeutic trials aimed at reducing fatigue.