E
Emmanuel Van Obberghen
Researcher at French Institute of Health and Medical Research
Publications - 125
Citations - 8929
Emmanuel Van Obberghen is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Insulin receptor & Insulin receptor substrate. The author has an hindex of 49, co-authored 124 publications receiving 8543 citations. Previous affiliations of Emmanuel Van Obberghen include University of Nice Sophia Antipolis & Centre national de la recherche scientifique.
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Journal ArticleDOI
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway.
Caroline Treins,Sophie Giorgetti-Peraldi,Joseph Murdaca,Gregg L. Semenza,Emmanuel Van Obberghen +4 more
TL;DR: It is shown that insulin regulates HIF-1 action through a PI3K/TOR-dependent pathway, resulting in increased VEGF expression in retinal epithelial cells.
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Matrix Metalloproteinases Are Differentially Expressed in Adipose Tissue during Obesity and Modulate Adipocyte Differentiation
Carine Chavey,Bernard Mari,Marie-Noëlle Monthouel,Stéphanie Bonnafous,Patrick Anglard,Emmanuel Van Obberghen,Sophie Tartare-Deckert +6 more
TL;DR: Findings support a role for the MMP/TIMP system in the control of proteolytic events and adipogenesis during obesity-mediated fat mass development.
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miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells
Abdelfattah El Ouaamari,Nadine Baroukh,Geert A. Martens,Patricia Lebrun,Daniel Pipeleers,Emmanuel Van Obberghen +5 more
TL;DR: Evidence is provided for a role of a pancreatic-specific microRNA, miR-375, in the regulation of PDK1, a key molecule in PI 3-kinase signaling in pancreatic β-cells.
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MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell Lines
Nadine Baroukh,Magalie A. Ravier,Merewyn K. Loder,Elaine V. Hill,Ali Bounacer,Raphael Scharfmann,Raphael Scharfmann,Guy A. Rutter,Emmanuel Van Obberghen,Emmanuel Van Obberghen +9 more
TL;DR: The precise role of microRNA-124a2 in pancreatic development remains to be deciphered, but it is identified as a regulator of a key transcriptional protein network in β-cells responsible for modulating intracellular signaling.
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Malnutrition is an independent factor associated with nosocomial infections
Stéphane M. Schneider,Patricia Veyres,Xavier Pivot,Anne-Marie Soummer,Patrick Jambou,Jérôme Filippi,Emmanuel Van Obberghen,Xavier Hébuterne +7 more
TL;DR: In non-selected hospitalized patients, malnutrition assessed with a simple and objective marker is an independent risk factor for nosocomial infections, and an early screening for malnutrition may therefore be helpful to reduce the high prevalence of NI.