V
Virginie Bottero
Researcher at Rosalind Franklin University of Medicine and Science
Publications - 54
Citations - 4016
Virginie Bottero is an academic researcher from Rosalind Franklin University of Medicine and Science. The author has contributed to research in topics: Kaposi's sarcoma-associated herpesvirus & Transcription factor. The author has an hindex of 31, co-authored 53 publications receiving 3609 citations. Previous affiliations of Virginie Bottero include French Institute of Health and Medical Research & Salk Institute for Biological Studies.
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Journal ArticleDOI
IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
Nagaraj Kerur,Mohanan Valiya Veettil,Neelam Sharma-Walia,Virginie Bottero,Sathish Sadagopan,Pushpalatha Otageri,Bala Chandran +6 more
TL;DR: IFI16 is revealed as a nuclear pathogen sensor and it is demonstrated that the inflammasome also functions in the nucleus.
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Gene therapy: therapeutic gene causing lymphoma.
Niels-Bjarne Woods,Virginie Bottero,Manfred Schmidt,Manfred Schmidt,Christof von Kalle,Inder M. Verma +5 more
TL;DR: Using a mouse model for gene therapy of X-SCID, it is found that the corrective therapeutic gene IL2RG itself can act as a contributor to the genesis of T-cell lymphomas, with one-third of animals being affected.
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Activation of Transcription Factor NF-κB Requires ELKS, an IκB Kinase Regulatory Subunit
Jeanette L. Ducut Sigala,Virginie Bottero,David B. Young,Andrej Shevchenko,Frank Mercurio,Inder M. Verma +5 more
TL;DR: ELKS likely functions by recruiting IκBα to the IKK complex and thus serves a regulatory function for IKK activation, and is likely not protected from apoptosis in response to cytokines.
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NF-κB modulation and ionizing radiation: mechanisms and future directions for cancer treatment
Nicolas Magné,Robert-Alain Toillon,Virginie Bottero,Céline Didelot,Paul Van Houtte,Jean-Pierre Gérard,Jean-François Peyron +6 more
TL;DR: The therapeutic potential of targeting NF-kappaB in cancer in particular during radiotherapy is discussed and the concept that NF- kappaB blockade could be associated to conventional therapies in order to increase their efficiency is discussed.
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IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy.
TL;DR: The results reveal an additional pathway of activating NF-κB during the course of anticancer therapy and provide a mechanistic basis for the observation that proteasome inhibitors could be used as adjuvants in chemotherapy.