J
Jean Gosselin
Researcher at Laval University
Publications - 5
Citations - 464
Jean Gosselin is an academic researcher from Laval University. The author has contributed to research in topics: Innate immune system & Viral load. The author has an hindex of 5, co-authored 5 publications receiving 417 citations.
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Journal ArticleDOI
Acquisition of a multifunctional IgA + plasma cell phenotype in the gut
Jörg H. Fritz,Jörg H. Fritz,Olga L. Rojas,Nathalie Simard,Nathalie Simard,Douglas D. McCarthy,Siegfried Hapfelmeier,Siegfried Hapfelmeier,Stephen Rubino,Susan J. Robertson,Mani Larijani,Mani Larijani,Jean Gosselin,Ivaylo I. Ivanov,Alberto Martin,Rafael Casellas,Dana J. Philpott,Stephen E. Girardin,Kathy D. McCoy,Andrew J. Macpherson,Christopher J. Paige,Christopher J. Paige,Jennifer L. Gommerman +22 more
TL;DR: It is reported that mouse IgA+ plasma cells also produce the antimicrobial mediators tumour-necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS), and express many molecules that are commonly associated with monocyte/granulocytic cell types.
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TLR9 Contributes to the Recognition of EBV by Primary Monocytes and Plasmacytoid Dendritic Cells
TL;DR: It is demonstrated that treatment of primary monocytes with EBV and with purified EBV DNA induced the release of IL-8 through TLR9, providing evidence of a dual action of TLR2 andTLR9 in EBV recognition by monocytes.
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Leukotriene B4, an endogenous stimulator of the innate immune response against pathogens.
TL;DR: This review will focus on the modulator effects of LTB4 on the innate defenses and discuss its therapeutic potential against viral pathogens.
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Involvement of TLR2 in Recognition of Acute Gammaherpesvirus-68 Infection
TL;DR: The results suggest that the TLR2 pathway has a relevant role in the recognition of this virus and in the subsequent activation of the innate immune response.
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Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection
TL;DR: The data suggest that both the TRIF and IPS-1 signaling pathways are important for the control of HSV replication in the brain and survival through IFN-β production.