C
Christopher J. Paige
Researcher at Princess Margaret Cancer Centre
Publications - 148
Citations - 12781
Christopher J. Paige is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: B cell & Progenitor cell. The author has an hindex of 48, co-authored 147 publications receiving 12379 citations. Previous affiliations of Christopher J. Paige include University Health Network & Ontario Institute for Cancer Research.
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Journal ArticleDOI
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
Mark A. Lomaga,Wen Chen Yeh,Ildiko Sarosi,Gordon S. Duncan,Caren Furlonger,Alexandra Ho,Sean Morony,Casey Capparelli,Gwyneth Van,Stephen Kaufman,Annette Van Der Heiden,Annick Itie,Andrew Wakeham,Wilson Khoo,Takehiko Sasaki,Zhaodan Cao,Josef M. Penninger,Christopher J. Paige,David L. Lacey,Colin R. Dunstan,William J. Boyle,David V. Goeddel,Tak W. Mak +22 more
TL;DR: It is reported that mice deficient in TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function, and it is demonstrated that TRAF6 is crucial not only in IL-1 and CD40 signaling but also, surprisingly, in LPS signaling.
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Profound block in thymocyte development in mice lacking p56lck.
Thierry Molina,Kenji Kishihara,D. P. Siderovskid,W. van Ewijk,Arumugavadivel Narendran,Emma Timms,Andrew Wakeham,Christopher J. Paige,K.-U. Hartmann,A. Veillette,D. Davidson,T. W. Mak +11 more
TL;DR: The results illustrate the crucial role of this T-cell-specific tyrosine kinase in the thymocyte development, as Lck-deficient mice show a pronounced thymic atrophy, with a dramatic reduction in the double-positive (CD4+CD8+) thymocytes population.
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Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
Haruhiko Suzuki,Haruhiko Suzuki,Thomas M. Kündig,Caren Furlonger,Andrew Wakeham,Andrew Wakeham,Emma Timms,Emma Timms,Toshifumi Matsuyama,Toshifumi Matsuyama,Rudolf Schmits,Rudolf Schmits,John J. L. Simard,John J. L. Simard,Pamela S. Ohashi,Henrik Griesser,Tadatsugu Taniguchi,Christopher J. Paige,Tak W. Mak,Tak W. Mak +19 more
TL;DR: In mice lacking the interleukin-2 receptor beta chain (IL-2R beta), T cells were shown to be spontaneously activated, resulting in exhaustive differentiation of B cells into plasma cells and the appearance of high serum concentrations of immunoglobulins G1 and E as well as autoantibodies that cause hemolytic anemia.
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B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals
Florienne Loder,Bettina Mutschler,Robert J. Ray,Christopher J. Paige,Paschalis Sideras,Raul M. Torres,Marinus C. Lamers,Rita Carsetti +7 more
TL;DR: It is shown that selection into the mature pool is an active process and takes place in the spleen, and two populations of splenic B cells were identified as precursors for mature B cells.
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Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.
Amin Rahemtulla,Wai-Ping Fung-Leung,Marco W. Schilham,Thomas M. Kündig,S. R. Sambhara,Aru Narendran,A. Arabian,Andrew Wakeham,Christopher J. Paige,R. M. Zinkernagel,Richard G. Miller,T. W. Mak +11 more
TL;DR: In these mice, the development of CD8+ T cells and myeloid components is unaltered, indicating that expression of CD4 on progenitor cells and CD4+CD8+ (double positive) thymocytes is not obligatory, which is important to the understanding of immune disorders, including AIDS.