N
Nathalie Simard
Researcher at University of Toronto
Publications - 3
Citations - 231
Nathalie Simard is an academic researcher from University of Toronto. The author has contributed to research in topics: B cell & Precursor cell. The author has an hindex of 3, co-authored 3 publications receiving 213 citations. Previous affiliations of Nathalie Simard include University Health Network.
Papers
More filters
Journal ArticleDOI
Acquisition of a multifunctional IgA + plasma cell phenotype in the gut
Jörg H. Fritz,Jörg H. Fritz,Olga L. Rojas,Nathalie Simard,Nathalie Simard,Douglas D. McCarthy,Siegfried Hapfelmeier,Siegfried Hapfelmeier,Stephen Rubino,Susan J. Robertson,Mani Larijani,Mani Larijani,Jean Gosselin,Ivaylo I. Ivanov,Alberto Martin,Rafael Casellas,Dana J. Philpott,Stephen E. Girardin,Kathy D. McCoy,Andrew J. Macpherson,Christopher J. Paige,Christopher J. Paige,Jennifer L. Gommerman +22 more
TL;DR: It is reported that mouse IgA+ plasma cells also produce the antimicrobial mediators tumour-necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS), and express many molecules that are commonly associated with monocyte/granulocytic cell types.
Journal ArticleDOI
Interleukin-21 regulates expression of key Epstein-Barr virus oncoproteins, EBNA2 and LMP1, in infected human B cells.
TL;DR: It is shown that IL-21-reduced gene and protein expression of growth-transforming EBV nuclear antigen 2 (EBNA2) in OCI-BCLs is reduced and the expression of CD40-like, latent membrane protein 1 (LMP1) strongly increased in these cells suggesting an EBNA2-independent mode of regulation.
Journal ArticleDOI
Analysis of the Role of IL-21 in Development of Murine B Cell Progenitors in the Bone Marrow
Nathalie Simard,Danijela Konforte,Anne H. Tran,Jessica Esufali,Warren J. Leonard,Christopher J. Paige,Christopher J. Paige +6 more
TL;DR: Evidence that IL-21R is functional in B cell progenitors is provided and the number of mature IgMhiIgDhi cells was decreased in BM of IL- 21R–deficient mice is reported, indicating that IL -21 regulates B cell development.