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Dana J. Philpott
Researcher at University of Toronto
Publications - 243
Citations - 28955
Dana J. Philpott is an academic researcher from University of Toronto. The author has contributed to research in topics: Innate immune system & NOD1. The author has an hindex of 77, co-authored 223 publications receiving 25869 citations. Previous affiliations of Dana J. Philpott include Pasteur Institute & French Institute of Health and Medical Research.
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Journal ArticleDOI
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.
Stephen E. Girardin,Ivo G. Boneca,Jérôme Viala,Mathias Chamaillard,Agnès Labigne,Gilles Thomas,Dana J. Philpott,Philippe J. Sansonetti +7 more
TL;DR: It is shown here that Nod2 is a general sensor of peptidoglycan through the recognition of muramyl dipeptide (MDP), the minimal bioactive peptIDoglycan motif common to all bacteria.
Journal ArticleDOI
Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
Stephen E. Girardin,Ivo G. Boneca,Leticia A.M. Carneiro,Aude Antignac,Muguette Jéhanno,Jérôme Viala,Karsten Tedin,Muhamed-Kheir Taha,Agnès Labigne,Ulrich Zähringer,Anthony J. Coyle,Peter S. DiStefano,John Bertin,Philippe J. Sansonetti,Dana J. Philpott +14 more
TL;DR: It is shown that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine–N-acetelmuramic acid tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-κB pathway.
Journal ArticleDOI
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
Jérôme Viala,Catherine Chaput,Ivo G Boneca,Ana Cardona,Stephen E. Girardin,Anthony P. Moran,Rafika Athman,Sylvie Mémet,Michael R Huerre,Anthony J. Coyle,Peter S. DiStefano,Philippe J. Sansonetti,A Labigne,John Bertin,Dana J. Philpott,Dana J. Philpott,Richard L. Ferrero,Richard L. Ferrero +17 more
TL;DR: It is proposed that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens as well as an intracellular pathogen-recognition molecule with specificity for Gram-negative peptidoglycan.
Journal ArticleDOI
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
Leonardo H. Travassos,Leticia A.M. Carneiro,Mahendrasingh Ramjeet,Seamus Hussey,Seamus Hussey,Yun Gi Kim,Joao G. Magalhaes,Linda Yuan,Fraser Soares,Evelyn Chea,Lionel Le Bourhis,Ivo G Boneca,Abdelmounaaim Allaoui,Nicola L. Jones,Gabriel Núñez,Stephen E. Girardin,Dana J. Philpott +16 more
TL;DR: The results link bacterial sensing by Nod proteins to the induction of autophagy and provide a functional link between Nod2 and ATG16L1, which are encoded by two of the most important genes associated with Crohn's disease.
Journal ArticleDOI
Nod-like proteins in immunity, inflammation and disease.
TL;DR: An additional key function of Nod-like receptors is in inflammatory conditions, which has been emphasized by the identification of several different mutations in the genes encoding Nod1, Nod2 and NALP3 that are associated with susceptibility to inflammatory disorders.