J
Jean Leandro dos Santos
Researcher at Sao Paulo State University
Publications - 110
Citations - 2010
Jean Leandro dos Santos is an academic researcher from Sao Paulo State University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 23, co-authored 95 publications receiving 1473 citations. Previous affiliations of Jean Leandro dos Santos include Johns Hopkins University & University of São Paulo.
Papers
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The Prodrug Approach: A Successful Tool for Improving Drug Solubility
Daniela Hartmann Jornada,Guilherme Felipe dos Santos Fernandes,Diego Eidy Chiba,Thais Regina Ferreira de Melo,Jean Leandro dos Santos,Man Chin Chung +5 more
TL;DR: This review aims to describe recent advances in the improvement of solubility via the prodrug approach, highlighting the advances of this field in the last ten years.
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Boron in drug design: Recent advances in the development of new therapeutic agents
Guilherme Felipe dos Santos Fernandes,Guilherme Felipe dos Santos Fernandes,William A. Denny,Jean Leandro dos Santos +3 more
TL;DR: The present review is intended to highlight the recent advances related to boron-containing compounds and their therapeutic applications, and focused only in those most biologically active compounds with proven in-vitro and/or in vivo efficacy in the therapeutic area published in the last years.
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Unraveling the Anticancer Effect of Curcumin and Resveratrol.
Aline Renata Pavan,Gabriel Dalio Bernardes da Silva,Daniela Hartmann Jornada,Diego Eidy Chiba,Guilherme Felipe dos Santos Fernandes,Chung Man Chin,Jean Leandro dos Santos +6 more
TL;DR: This work analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years in order to unravel the molecular mechanism of action of both compounds.
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Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives
Jean Leandro dos Santos,Paulo Renato Yamasaki,Chung Man Chin,Celio H. Takashi,Fernando Rogério Pavan,Clarice Queico Fujimura Leite +5 more
TL;DR: New phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis.
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Epigenetic Regulatory Mechanisms Induced by Resveratrol.
Guilherme Felipe dos Santos Fernandes,Gabriel Dalio Bernardes da Silva,Aline Renata Pavan,Diego Eidy Chiba,Chung Man Chin,Jean Leandro dos Santos +5 more
TL;DR: The biological activities exhibited by RVT are analyzed with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase, histone deacetylase and lysine-specific demethylase-1 (LSD1).