J
Jean M. Watermeyer
Researcher at University of Cape Town
Publications - 13
Citations - 588
Jean M. Watermeyer is an academic researcher from University of Cape Town. The author has contributed to research in topics: Glycosylation & Domain (software engineering). The author has an hindex of 11, co-authored 13 publications receiving 511 citations. Previous affiliations of Jean M. Watermeyer include Birkbeck, University of London.
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Journal ArticleDOI
Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs
Sujaan Das,Nadine Hertrich,Abigail J. Perrin,Chrislaine Withers-Martinez,Christine R. Collins,Matthew L. Jones,Jean M. Watermeyer,Elmar T. Fobes,Stephen R. Martin,Helen R. Saibil,Gavin J. Wright,Moritz Treeck,Christian Epp,Michael J. Blackman,Michael J. Blackman +14 more
TL;DR: These results indicate that interactions between SUB1-processed merozoite surface MSP1 and the spectrin network of the erythrocyte cytoskeleton facilitate host ery throatyte rupture to enable parasite egress.
Journal ArticleDOI
Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress
Victoria L. Hale,Jean M. Watermeyer,Fiona Hackett,Gema Vizcay-Barrena,Christiaan van Ooij,James A. Thomas,Matthew C. Spink,Maria Harkiolaki,Elizabeth Duke,Roland A. Fleck,Michael J. Blackman,Michael J. Blackman,Helen R. Saibil +12 more
TL;DR: This work describes a previously unidentified permeabilization of the vacuolar membrane at the start of egress, preceding membrane rupture, suggesting a new initiation step in egress and shows that host cell cytoskeleton breakdown is restricted to a narrow time window within the final stages of Egress.
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Symmetry-Restrained Flexible Fitting for Symmetric EM Maps
Kwok Yan Chan,James C. Gumbart,Ryan McGreevy,Jean M. Watermeyer,B. Trevor Sewell,Klaus Schulten +5 more
TL;DR: The symmetry-restrained MDFF method is developed, which adds to the cryo-EM map-derived potential further restraints on the allowed conformations of a complex during fitting, thereby improving the quality of the resultant structure.
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A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum–infected erythrocytes
Jean M. Watermeyer,Victoria L. Hale,Fiona Hackett,Daniel K. Clare,Erin E. Cutts,Ioannis Vakonakis,Roland A. Fleck,Michael J. Blackman,Michael J. Blackman,Helen R. Saibil +9 more
TL;DR: Ierythrocyte knobs in P falciparum infection contain a highly organized skeleton structure underlying a specialized region of membrane, which suggests an explanation for the rigidification of the cytoskeleton in infected cells, and for the transmission of shear forces experienced by adhering cells.
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Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme
TL;DR: In this article, the cocrystal structures of human testis ACE, equivalent to the C domain, have been determined with two novel C domain-selective ketomethylene inhibitors.