J
Jean-Philippe Brosseau
Researcher at University of Texas Southwestern Medical Center
Publications - 29
Citations - 1169
Jean-Philippe Brosseau is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: RNA splicing & Alternative splicing. The author has an hindex of 12, co-authored 27 publications receiving 824 citations. Previous affiliations of Jean-Philippe Brosseau include Centre Hospitalier Universitaire de Sherbrooke & Université de Sherbrooke.
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Journal ArticleDOI
Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours.
Han Yao,Jiang Lan,Chushu Li,Hubing Shi,Jean-Philippe Brosseau,Huanbin Wang,Haojie Lu,Caiyun Fang,Yao Zhang,Lunxi Liang,Xiaolin Zhou,Chaojun Wang,Yu Xue,Yun Cui,Jie Xu +14 more
TL;DR: It is shown that PD-L1 is palmitoylated in its cytoplasmic domain, and that this lipid modification stabilizes PD-l1 by blocking its ubiquitination, consequently suppressing PD- L1 degradation by lysosomes.
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Identification of alternative splicing markers for breast cancer.
Julian P. Venables,Roscoe Klinck,Anne Bramard,Lyna Inkel,Geneviève Dufresne-Martin,ChuShin Koh,Julien Gervais-Bird,Elvy Lapointe,Ulrike Froehlich,Mathieu Durand,Daniel Gendron,Jean-Philippe Brosseau,Philippe Thibault,Jean-François Lucier,Karine Tremblay,Panagiotis Prinos,Raymund J. Wellinger,Benoit Chabot,Claudine Rancourt,Sherif Abou Elela +19 more
TL;DR: A new approach for the identification of breast cancer markers that does not measure gene expression but instead uses the ratio of alternatively spliced mRNAs as its indicator is presented, providing a simple alternative for the classification of normal and cancerous breast tumor tissues and underscore the putative role of alternative splicing in the biology of cancer.
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RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues.
Julian P. Venables,Jean-Philippe Brosseau,Gilles Gadea,Roscoe Klinck,Panagiotis Prinos,Jean-François Beaulieu,Elvy Lapointe,Mathieu Durand,Philippe Thibault,Karine Tremblay,François Rousset,Jamal Tazi,Sherif Abou Elela,Benoit Chabot +13 more
TL;DR: By knocking down 78 potential splicing factors in five cell lines, this work provides an extensive view of the complex regulatory landscape associated with the epithelial and mesenchymal states, thus revealing that RBFOX2 is an important driver of mesenchyal tissue-specific splicing.
Journal ArticleDOI
Alternative splicing of SYK regulates mitosis and cell survival
Panagiotis Prinos,Daniel Garneau,Jean-François Lucier,Daniel Gendron,Sonia Couture,Marianne Boivin,Jean-Philippe Brosseau,Elvy Lapointe,Philippe Thibault,Mathieu Durand,Karine Tremblay,Julien Gervais-Bird,Hanad Nwilati,Roscoe Klinck,Benoit Chabot,Jean-Pierre Perreault,Raymund J. Wellinger,Sherif Abou Elela +17 more
TL;DR: The data suggest that splicing of selected genes is specifically modified during tumor development to allow the expression of isoforms that promote cancer cell survival, including the pro-survival isoform that is associated with cancer tissues in vivo.
Journal ArticleDOI
Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis
Chung Ping Liao,Reid C. Booker,Jean-Philippe Brosseau,Zhiguo Chen,Juan Mo,Edem Tchegnon,Yong Wang,D. Wade Clapp,Lu Q. Le +8 more
TL;DR: In this article, the role of inflammation in neurofibromagenesis was investigated in a genetically engineered Scf mice to decipher the contributions of tumor-derived SCF and mast cells to neuro-fibroma development and showed that mast cell infiltration is dependent on SCF from tumor Schwann cells.