J
Jie Xu
Researcher at University of Texas MD Anderson Cancer Center
Publications - 131
Citations - 4481
Jie Xu is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 32, co-authored 83 publications receiving 3150 citations. Previous affiliations of Jie Xu include Flanders Institute for Biotechnology & Shanghai Jiao Tong University.
Papers
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Journal ArticleDOI
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
Jie Xu,Joke Reumers,José R. Couceiro,Frederik De Smet,Rodrigo Gallardo,Stanislav Rudyak,Ann Cornelis,Jef Rozenski,Aleksandra Zwolinska,Jean-Christophe Marine,Diether Lambrechts,Young-Ah Suh,Frederic Rousseau,Joost Schymkowitz +13 more
TL;DR: This study reveals a novel disease mechanism for mutant p53 gain of function and suggests that, at least in some respects, cancer could be considered an aggregation-associated disease.
Journal ArticleDOI
The ABORTED MICROSPORES Regulatory Network Is Required for Postmeiotic Male Reproductive Development in Arabidopsis thaliana
Jie Xu,Caiyun Yang,Zheng Yuan,Zheng Yuan,Dasheng Zhang,Martha Y. Gondwe,Zhiwen Ding,Wanqi Liang,Dabing-B. Zhang,Zoe A. Wilson +9 more
TL;DR: It is shown by microarray analysis that the expression of 549 anther-expressed genes was altered in ams buds and that these genes are associated with tapetal function and pollen wall formation, and it is demonstrated that AMS has the ability to bind in vitro to DNA containing a 6-bp consensus motif, CANNTG.
Journal ArticleDOI
Long Noncoding RNA GAPLINC Regulates CD44-Dependent Cell Invasiveness and Associates with Poor Prognosis of Gastric Cancer
Ye Hu,Ji-Lin Wang,Jin Qian,Xuan Kong,Jie-Ting Tang,Ying-Chao Wang,Haoyan Chen,Jie Hong,Weiping Zou,Ying-Xuan Chen,Jie Xu,Jing-Yuan Fang +11 more
TL;DR: Findings implicating a novel lncRNA in gastric cancer, termed GAPLINC (gastric adenocarcinoma predictive long intergenic noncoding RNA), are reported based on the use of global microarray and in situ hybridization (ISH) analyses to identify aberrantly expressed lnc RNA in human Gastric cancer specimens.
Journal ArticleDOI
Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours.
Han Yao,Jiang Lan,Chushu Li,Hubing Shi,Jean-Philippe Brosseau,Huanbin Wang,Haojie Lu,Caiyun Fang,Yao Zhang,Lunxi Liang,Xiaolin Zhou,Chaojun Wang,Yu Xue,Yun Cui,Jie Xu +14 more
TL;DR: It is shown that PD-L1 is palmitoylated in its cytoplasmic domain, and that this lipid modification stabilizes PD-l1 by blocking its ubiquitination, consequently suppressing PD- L1 degradation by lysosomes.
Book ChapterDOI
Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond.
Luoyan Ai,Antao Xu,Jie Xu +2 more
TL;DR: Clinically, antibodies targeting PD-1/PD-L1 reinvigorate the "exhausted" T cells in TME and show remarkable objective response and durable remission with acceptable toxicity profile in large numbers of tumors such as melanoma, lymphoma, and mismatch-repair deficient tumors.