J
Jean-Philippe Desilles
Researcher at University of Paris
Publications - 111
Citations - 2686
Jean-Philippe Desilles is an academic researcher from University of Paris. The author has contributed to research in topics: Stroke & Medicine. The author has an hindex of 23, co-authored 86 publications receiving 1621 citations. Previous affiliations of Jean-Philippe Desilles include Boston Children's Hospital & Sorbonne.
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Journal ArticleDOI
Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke.
Célina Ducroux,Lucas Di Meglio,Stéphane Loyau,Sandrine Delbosc,William Boisseau,Catherine Deschildre,Malek Ben Maacha,Raphaël Blanc,H Redjem,Gabriele Ciccio,Stanislas Smajda,Robert Fahed,Jean-Baptiste Michel,Michel Piotin,Laurence Salomon,Mikael Mazighi,Benoît Ho-Tin-Noé,Jean-Philippe Desilles +17 more
TL;DR: Thrombus NETs content may be responsible for reperfusion resistance, including mechanical or pharmacological approaches with intravenous tPA, irrespectively of their etiology.
Journal ArticleDOI
Diabetes Mellitus, Admission Glucose, and Outcomes After Stroke Thrombolysis: A Registry and Systematic Review
Jean-Philippe Desilles,Elena Meseguer,Julien Labreuche,Bertrand Lapergue,Gaia Sirimarco,Jaime Gonzalez-Valcarcel,Philippa C. Lavallée,Lucie Cabrejo,Céline Guidoux,Isabelle F. Klein,Pierre Amarenco,Mikael Mazighi +11 more
TL;DR: It is confirmed that AGL and history of diabetes mellitus are associated with poor clinical outcome after thrombolysis and AGL may be a surrogate marker of brain infarction severity rather than a causal factor.
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Treatment of Acute Ischemic Stroke due to Large Vessel Occlusion With COVID-19: Experience From Paris.
Simon Escalard,Benjamin Maïer,Hocine Redjem,François Delvoye,Solène Hebert,Stanislas Smajda,Gabriele Ciccio,Jean-Philippe Desilles,Mikael Mazighi,Raphaël Blanc,Michel Piotin +10 more
TL;DR: Best medical care including early intravenous thrombolysis, and successful and prompt recanalization achieved with mechanical thrombectomy, resulted in poor outcomes in patients with COVID-19.
Journal ArticleDOI
Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke
Jean-Philippe Desilles,Stéphane Loyau,Varouna Syvannarath,Jaime Gonzalez-Valcarcel,Marie Cantier,Liliane Louedec,Bertrand Lapergue,Pierre Amarenco,Nadine Ajzenberg,Martine Jandrot-Perrus,Jean-Baptiste Michel,Benoît Ho-Tin-Noé,Mikael Mazighi +12 more
TL;DR: It is shown that alteplase-dependent maintenance of downstream perfusion during MCAO improves acute ischemic stroke outcome through a fibrinogen-dependent platelet aggregation reduction.
Journal ArticleDOI
Impact of Modified TICI 3 versus Modified TICI 2b Reperfusion Score to Predict Good Outcome following Endovascular Therapy.
Cyril Dargazanli,Arturo Consoli,M. Barral,Julien Labreuche,Hocine Redjem,Gabriele Ciccio,Stanislas Smajda,Jean-Philippe Desilles,Guillaume Taylor,Cristian Preda,Oguzhan Coskun,G. Rodesch,Michel Piotin,Raphaël Blanc,Bertrand Lapergue +14 more
TL;DR: Given the improving reperfusion rates obtained with thrombectomy devices, future thromBectomy trials should consider modified TicI 2b and modified TICI 3 status separately.