S
Stéphane Loyau
Researcher at University of Paris
Publications - 63
Citations - 2479
Stéphane Loyau is an academic researcher from University of Paris. The author has contributed to research in topics: GPVI & Platelet. The author has an hindex of 27, co-authored 61 publications receiving 1952 citations. Previous affiliations of Stéphane Loyau include French Institute of Health and Medical Research & Sorbonne.
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Journal ArticleDOI
Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke.
Célina Ducroux,Lucas Di Meglio,Stéphane Loyau,Sandrine Delbosc,William Boisseau,Catherine Deschildre,Malek Ben Maacha,Raphaël Blanc,H Redjem,Gabriele Ciccio,Stanislas Smajda,Robert Fahed,Jean-Baptiste Michel,Michel Piotin,Laurence Salomon,Mikael Mazighi,Benoît Ho-Tin-Noé,Jean-Philippe Desilles +17 more
TL;DR: Thrombus NETs content may be responsible for reperfusion resistance, including mechanical or pharmacological approaches with intravenous tPA, irrespectively of their etiology.
Journal ArticleDOI
Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.
Elmina Mammadova-Bach,Véronique Ollivier,Véronique Ollivier,Stéphane Loyau,Stéphane Loyau,Mathieu Schaff,Bénédicte Dumont,Bénédicte Dumont,Rémi Favier,Geneviève Freyburger,Véronique Latger-Cannard,Bernhard Nieswandt,Christian Gachet,Pierre Mangin,Martine Jandrot-Perrus,Martine Jandrot-Perrus +15 more
TL;DR: GPVI is identified as a platelet receptor for polymerized fibrin with 2 major functions: amplification of thrombin generation and recruitment of circulating platelets to clots.
Journal ArticleDOI
Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice.
Angèle Gros,Angèle Gros,Varouna Syvannarath,Varouna Syvannarath,Lamia Lamrani,Lamia Lamrani,Véronique Ollivier,Véronique Ollivier,Stéphane Loyau,Stéphane Loyau,Tobias Goerge,Bernhard Nieswandt,Martine Jandrot-Perrus,Martine Jandrot-Perrus,Benoît Ho-Tin-Noé,Benoît Ho-Tin-Noé +15 more
TL;DR: Results show that GPVI plays a dual role in inflammation by enhancing neutrophil-damaging activities while supporting the activation and hemostatic adhesion of single platelets to neutrophIL-induced vascular breaches.
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Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke
Jean-Philippe Desilles,Stéphane Loyau,Varouna Syvannarath,Jaime Gonzalez-Valcarcel,Marie Cantier,Liliane Louedec,Bertrand Lapergue,Pierre Amarenco,Nadine Ajzenberg,Martine Jandrot-Perrus,Jean-Baptiste Michel,Benoît Ho-Tin-Noé,Mikael Mazighi +12 more
TL;DR: It is shown that alteplase-dependent maintenance of downstream perfusion during MCAO improves acute ischemic stroke outcome through a fibrinogen-dependent platelet aggregation reduction.
Journal ArticleDOI
Inhibition of fibrinolysis by lipoprotein(a).
TL;DR: A high plasma concentration of lipoprotein Lp (a) is now considered to be a major and independent risk factor for cerebro‐ and cardiovascular atherothrombosis and high concentrations of Lp(a) in plasma may represent a potential source of antifibrinolytic activity.