J
Jedd D. Wolchok
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 795
Citations - 154490
Jedd D. Wolchok is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Ipilimumab & Immune system. The author has an hindex of 140, co-authored 713 publications receiving 123336 citations. Previous affiliations of Jedd D. Wolchok include Ludwig Institute for Cancer Research & University of York.
Papers
More filters
Journal ArticleDOI
Clinical efficacy and correlation with tumor PD-L1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475.
Richard F. Kefford,Antoni Ribas,Omid Hamid,Caroline Robert,Adil Daud,Jedd D. Wolchok,Anthony M. Joshua,F. Stephen Hodi,Tara C. Gangadhar,Peter Hersey,Jeffrey S. Weber,Roxana S. Dronca,Amita Patnaik,Hassane M. Zarour,Marisa Dolled-Filhart,Jared Lunceford,Kenneth Emancipator,Scot Ebbinghaus,Soonmo Peter Kang,Wen-Jen Hwu +19 more
TL;DR: MK-3475 demonstrated antitumor activity and acceptable safety in a phase I MEL cohort and updated efficacy data and correlation with tumor PD-L1 expression are provided.
Journal ArticleDOI
Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis.
Jun Li,Mercedes Duran,Ninjit Dhanota,Walid K. Chatila,Walid K. Chatila,Sarah E Bettigole,John Kwon,Roshan K. Sriram,Matthew P. Humphries,Manuel Salto-Tellez,Manuel Salto-Tellez,Jacqueline James,Matthew G. Hanna,Johannes C. Melms,Sreeram Vallabhaneni,Kevin Litchfield,Ieva Usaite,Dhruva Biswas,Rohan Bareja,Hao Wei Li,Maria Laura Martin,Princesca Dorsaint,Julie-Ann Cavallo,Peng Li,Chantal Pauli,Lee S. Gottesdiener,Benjamin J DiPardo,Travis J Hollmann,Taha Merghoub,Hannah Y Wen,Jorge S. Reis-Filho,Nadeem Riaz,Shin-San Michael Su,Anusha Kalbasi,Neil Vasan,Neil Vasan,Simon N. Powell,Jedd D. Wolchok,Olivier Elemento,Charles Swanton,Alexander N. Shoushtari,Alexander N. Shoushtari,Eileen Parkes,Eileen Parkes,Benjamin Izar,Samuel F. Bakhoum +45 more
TL;DR: In this article, the ectonucleotidase ENPP1 promotes metastasis by selectively degrading extracellular cGAMP, an immune-stimulatory metabolite whose breakdown products include the immune suppressor adenosine.
Journal ArticleDOI
Opportunistic infections in patients treated with immunotherapy for cancer.
TL;DR: The first reported case to the knowledge of an opportunistic infection in a patient treated with an immunomodulatory antibody is presented.
Journal ArticleDOI
Immunization with DNA coding for gp100 results in CD4+ T-cell independent antitumor immunity
William G. Hawkins,Jason S. Gold,Ruben Dyall,Jedd D. Wolchok,Axel Hoos,Wilbur B. Bowne,Roopa Srinivasan,Alan N. Houghton,Jonathan J. Lewis +8 more
TL;DR: Results show that xenogeneic DNA vaccines can lead to cancer immunity without CD4(+) T-cell help with potential implications for rational vaccine design.
Journal ArticleDOI
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment
Sadna Budhu,David Schaer,Yongbiao Li,Ricardo Toledo-Crow,Katherine S. Panageas,Xia Yang,Hong Zhong,Alan N. Houghton,Samuel C. Silverstein,Taha Merghoub,Jedd D. Wolchok,Jedd D. Wolchok +11 more
TL;DR: Ex vivo three-dimensional collagen-fibrin gel cultures of dissociated B16 melanoma tumors recapitulated the in vivo suppression of antimelanoma immunity, rendering the dissociated tumor cells resistant to killing by cocultured activated, antigen-specific T cells.