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Jeff Boyd

Researcher at Florida International University

Publications -  70
Citations -  13881

Jeff Boyd is an academic researcher from Florida International University. The author has contributed to research in topics: Tumor suppressor gene & Gene. The author has an hindex of 42, co-authored 69 publications receiving 13229 citations. Previous affiliations of Jeff Boyd include Research Triangle Park & University of Pennsylvania.

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Mutation Analysis of the BRCA1 Gene in Ovarian Cancers

TL;DR: The hypothesis that BRCA1 mutations are involved in the etiology of hereditary ovarian carcinomas but occur rarely in sporadic tumors, and that the frequent allelic loss on chromosome 17q in this cancer type reflects the involvement of an additional tumor suppressor gene(s), is supported.
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Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair.

TL;DR: The data suggest that the MSH3 gene encodes a product that functions in repair of some but not all pre-mutational intermediates, its mutation in tumours can result in genomic instability and, as in yeast, MSH 3 and MSH6 are partially redundant for mismatch repair.
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BRCA1, BRCA2, and hereditary nonpolyposis colorectal cancer gene mutations in an unselected ovarian cancer population: Relationship to family history and implications for genetic testing

TL;DR: The majority of ovarian cancer patients with suggestive family histories test negative for known gene mutations, perhaps suggesting the existence of additional undiscovered genes predisposing to ovarian cancer.
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The p53 tumor suppressor gene frequently is altered in gynecologic cancers.

TL;DR: Although mutation and overexpression of p53 rarely occur in cancers of the cervix, vulva, and vagina, it has been shown that human papillomavirus E6 oncoproteins bind to and inactivate p53 protein.