A
Andrew Berchuck
Researcher at Duke University
Publications - 617
Citations - 63537
Andrew Berchuck is an academic researcher from Duke University. The author has contributed to research in topics: Ovarian cancer & Cancer. The author has an hindex of 88, co-authored 568 publications receiving 56085 citations. Previous affiliations of Andrew Berchuck include Pennsylvania State University & Durham University.
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Journal ArticleDOI
Integrated genomic analyses of ovarian carcinoma
Debra A. Bell,Andrew Berchuck,Michael J. Birrer,Jeremy Chien,Daniel W. Cramer,Fanny Dao,Rajiv Dhir,Philip J. DiSaia,Hani Gabra,Pat Glenn,Andrew K. Godwin,John D. Gross,Lynn C. Hartmann,M. Huang,David G. Huntsman,Mary Iacocca,Marcin Imielinski,Steve E. Kalloger,Beth Y. Karlan,Beth Y. Karlan,Douglas A. Levine,Douglas A. Levine,Douglas A. Levine,Gordon B. Mills,Gordon B. Mills,Carl Morrison,David G. Mutch,Narciso Olvera,Sandra Orsulic,Kay J. Park,Nicholas J. Petrelli,Brenda Rabeno,Janet S. Rader,Branimir I. Sikic,Karen Smith-McCune,Anil K. Sood,David D.L. Bowtell,Robert Penny,Joseph R. Testa,Kyle Chang,Huyen Dinh,J. A. Drummond,G. Fowler,Preethi H. Gunaratne,A. C. Hawes,C. L. Kovar,L. R. Lewis,M. B. Morgan,I. F. Newsham,J. Santibanez,Jeffrey G. Reid,L. R. Trevino,Yue Wu,M. Wang,Donna M. Muzny,D. A. Wheeler,Richard A. Gibbs,Gad Getz,Gad Getz,Michael S. Lawrence,Michael S. Lawrence,Kristian Cibulskis,Kristian Cibulskis,Andrey Sivachenko,C. Sougnez,Douglas Voet,Douglas Voet,Jane Wilkinson,Toby Bloom,Kristin G. Ardlie,Kristin G. Ardlie,T. Fennell,Jennifer Baldwin,S. Gabriel,Eric S. Lander,Li Ding,Robert S. Fulton,Daniel C. Koboldt,Michael D. McLellan,Todd Wylie,Jason Walker,M. O'Laughlin,D. J. Dooling,Linnea Fulton,R. Abbott,N. D. Dees,Qizhou Zhang,Cyriac Kandoth,Michael C. Wendl,William Schierding,D. Shen,Chris Harris,Hayden R. Schmidt,Joelle Kalicki,K. D. Delehaunty,Catrina Fronick,Ryan Demeter,L. Cook,J. W. Wallis,L. Lin,Vincent Magrini,J. S. Hodges,James M. Eldred,S. M. Smith,Craig Pohl,Fabio Vandin,Benjamin J. Raphael,George M. Weinstock,Elaine R. Mardis,Richard K. Wilson,Matthew Meyerson,Wendy Winckler,R. G.W. Verhaak,Suzie Carter,Craig H. Mermel,G. Saksena,G. Saksena,H. Nguyen,R. C. Onofrio,D. Hubbard,S. Gupta,A. Crenshaw,A. H. Ramos,Lynda Chin,Lynda Chin,Alexei Protopopov,Jinghui Zhang,Jinghui Zhang,Jinghui Zhang,T. M. Kim,Ilana Perna,Y. Xiao,Hailei Zhang,Gang Ren,N. Sathiamoorthy,R. W. Park,R. W. Park,Eunjung Lee,Peter J. Park,Peter J. Park,Raju Kucherlapati,D. M. Absher,L. Waite,Gavin Sherlock,James D. Brooks,Jun Li,Jian Xu,Richard M. Myers,Peter W. Laird,L. Cope,James G. Herman,H. Shen,Daniel J. Weisenberger,Houtan Noushmehr,F. Pan,Timothy J. Triche,Benjamin P. Berman,D. J. Van Den Berg,J. Buckley,Stephen B. Baylin,Paul T. Spellman,Paul T. Spellman,Elizabeth Purdom,Pierre Neuvial,Pierre Neuvial,Henrik Bengtsson,Henrik Bengtsson,L. R. Jakkula,S. Durinck,S. Durinck,Junhong Han,Junhong Han,S. Dorton,H. Marr,Y. G. Choi,V. Wang,N. J. Wang,J. Ngai,J. G. Conboy,Bahram Parvin,H. S. Feiler,Terence P. Speed,Joe W. Gray,Joe W. Gray,N. D. Socci,Yanke Liang,Barry S. Taylor,Nikolaus Schultz,Nikolaus Schultz,L. Borsu,Alex E. Lash,Cameron Brennan,A. Viale,Chris Sander,M. Ladanyi,M. Ladanyi,Katherine A. Hoadley,Katherine A. Hoadley,S. Meng,Y. Du,Y. Du,Yigong Shi,Lulin Li,Y. J. Turman,D. Zang,E. B. Helms,S. Balu,Xiang Zhou,Jane Y. Wu,M. D. Topal,D. N. Hayes,D. N. Hayes,Charles M. Perou,Chaowei Wu,S. Shukla,A. Sivachenko,R. Jing,Yingkai Liu,M. Noble,Hannah Carter,D. Kim,Rachel Karchin,James E. Korkola,Laura M. Heiser,Raymond J. Cho,Zhi Hu,Ethan Cerami,A. Olshen,B. Reva,Yevgeniy Antipin,R. Shen,P. Mankoo,Robert L. Sheridan,Giovanni Ciriello,William K. Chang,J. A. Bernanke,David Haussler,Christopher C. Benz,Joshua M. Stuart,Stephen C. Benz,J. Z. Sanborn,Charles J. Vaske,Jieqing Zhu,Christopher Szeto,G. K. Scott,Christina Yau,Matthew D. Wilkerson,N. Zhang,Rehan Akbani,Keith A. Baggerly,W. K. Yung,John N. Weinstein,T. Shelton,Dirk Grimm,Martha Hatfield,Scott Morris,P. Yena,P. Rhodes,Mark E. Sherman,J. Paulauskis,S. Millis,A. Kahn,John M. Greene,R. Sfeir,M. A. Jensen,John W. Chen,J. Whitmore,S. Alonso,J. Jordan,A. Chu,A. Barker,Carolyn C. Compton,Greg Eley,Martin L. Ferguson,Peter Fielding,Daniela S. Gerhard,R. Myles,Carl F. Schaefer,K. R. Mills Shaw,Jim Vaught,J. B. Vockley,Peter J. Good,Mark S. Guyer,Bradley A. Ozenberger,Jane Peterson,Elizabeth J. Thomson +285 more
TL;DR: It is reported that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1,BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes.
Integrated genomic analyses of ovarian carcinoma
Daphne W. Bell,Andrew Berchuck,Michael J. Birrer,Jeremy Chien,Daniel W. Cramer,Fanny Dao,Rajiv Dhir,Philip J. DiSaia,Hani Gabra,Pat Glenn,Andrew K. Godwin,John D. Gross,Lynn C. Hartmann,Mei Huang,David G. Huntsman,Mary Iacocca,Marcin Imielinski,Steve E. Kalloger,Beth Y. Karlan,Douglas A. Levine,Gordon B. Mills,Carolyn A. Morrison,David G. Mutch,Narciso Olvera,Sandra Orsulic,Kay J. Park,Nicholas J. Petrelli,Brenda Rabeno,Janet S. Rader,Branimir I. Sikic,Karen Smith-McCune,Anil K. Sood,David D.L. Bowtell,Robert Penny,Joseph R. Testa,Kyle Chang,Huyen Dinh,Jennifer Drummond,Gerald R. Fowler,Preethi H. Gunaratne,Alicia Hawes,Christie Kovar,Lora Lewis,Margaret B. Morgan,Irene Newsham,Jireh Santibanez,Jeffrey G. Reid,Lisa R. Trevino,Yuan Qing Wu,Min Wang,Donna Muzny,D Wheeler,Richard A. Gibbs,Gad Getz,Michael S. Lawrence,Kristian Cibulskis,Andrey Sivachenko,Carrie Sougnez,Douglas Voet,Jane Wilkinson,Toby Bloom,Kristin G. Ardlie,T. J. Fennell,Jennifer Baldwin,S. Gabriel,Eric S. Lander,Li Ding,Robert S. Fulton,Daniel C. Koboldt,Michael D. McLellan,Todd Wylie,Jason Walker,Michelle D O'Laughlin,David J. Dooling,Linnea Fulton,Rachel Abbott,Nathan D. Dees,Qizhou Zhang,Cyriac Kandoth,Michael C. Wendl,William Schierding,D. Shen,Chris Harris,Heather K. Schmidt,Joelle Kalicki,Kimberly D. Delehaunty,Catrina Fronick,Ryan Demeter,Linda S. Cook,John W. Wallis,Ling Lin,Vincent Magrini,Jennifer S. Hodges,James M. Eldred,Shaleigh Smith,Craig Pohl,Fabio Vandin,Benjamin J. Raphael,George M. Weinstock,Elaine R. Mardis,Richard K. Wilson,Matthew Meyerson,Wendy Winckler,Roeland Verhaak,Suzie Carter,Craig H. Mermel,Gordon Saksena,Huy V. Nguyen,Robert C. Onofrio,Diana D. Hubbard,Sonal Gupta,Andrew Crenshaw,Alex H. Ramos,Lynda Chin,Alexei Protopopov,Juinhua Zhang,T. M. Kim,Ilana Perna,Yonghong Xiao,Hailei Zhang,Gang Ren,Narayanan Sathiamoorthy,Richard W. Park,Eunjung Lee,Peter J. Park,Raju Kucherlapati,Devin Absher,Lindsay L. Waite,Gavin Sherlock,James D. Brooks,Jun Li,Jian Xu,Richard M. Myers,Peter W. Laird,Leslie Cope,James G. Herman,Hui Shen,Daniel J. Weisenberger,Houtan Noushmehr,Fei Pan,Timothy J. Triche,Benjamin P. Berman,D. J. Van Den Berg,Jonathan D. Buckley,Stephen B. Baylin,P. Spellman,Elizabeth Purdom,Pierre Neuvial,Henrik Bengtsson,Lakshmi Jakkula,Steffen Durinck,Junhong Han,Shannon Dorton,Henry Marr,Y. G. Choi,V. Wang,N. J. Wang,J. Ngai,John G. Conboy,Bahram Parvin,Heidi S. Feiler,Terence P. Speed,Joe W. Gray,Nicholas D. Socci,Yanke Liang,Barry S. Taylor,Nikolaus Schultz,Laetitia Borsu,Alex E. Lash,Cameron Brennan,Agnes Viale,Chris Sander,M. Ladanyi,Katherine A. Hoadley,Shaowu Meng,Ying Du,Yan Shi,Lulin Li,Yidi J. Turman,D. Zang,E. B. Helms,Saianand Balu,Xiang Zhou,Jane Y. Wu,Michael D. Topal,David N. Hayes,Charles M. Perou,Junihua Zhang,Chaowei Wu,Sachet A. Shukla,Andrey Sivachenko,Rui Jing,Yingkai Liu,Michael S. Noble,Hannah Carter,D. Kim,Rachel Karchin,James E. Korkola,Laura M. Heiser,Raymond J. Cho,Zhi Hu,Ethan Cerami,Adam B. Olshen,Boris Reva,Yevgeniy Antipin,Ronglai Shen,Parminder K. Mankoo,Rachael Sheridan,Giovanni Ciriello,William K. Chang,J. A. Bernanke,David Haussler,Christopher C. Benz,Joshua M. Stuart,Stephen C. Benz,John Zachary Sanborn,Charles J. Vaske,Jingchun Zhu,Christopher Szeto,Gary K. Scott,Christina Yau,Matthew D. Wilkerson,Nianxiang Zhang,Rehan Akbani,Keith A. Baggerly,W. K. Yung,John N. Weinstein,Troy Shelton,Dirk Grimm,Martha Hatfield,Shannon R. Morris,Peggy Yena,P. Rhodes,Mark E. Sherman,Joseph Paulauskis,S. Millis,Ari B. Kahn,John M. Greene,Robert Sfeir,Mark A. Jensen,John W. Chen,Jon Whitmore,Shelley Alonso,Justin T. Jordan,Anna L. Chu,Jinghui Zhang,Anna D. Barker,Carolyn C. Compton,Greg Eley,Martin L. Ferguson,Peter Fielding,Daniela S. Gerhard,R. Myles,Carl F. Schaefer,K. R. Mills Shaw,Jim Vaught,J. B. Vockley,Peter J. Good,Mark S. Guyer,Bradley A. Ozenberger,Jessica L. Peterson,E. Thomson +261 more
TL;DR: The Cancer Genome Atlas project has analyzed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours as mentioned in this paper.
Journal ArticleDOI
Integrated genomic characterization of endometrial carcinoma
Gad Getz,Stacey Gabriel,Kristian Cibulskis,Eric S. Lander,Andrey Sivachenko,Carrie Sougnez,Michael S. Lawrence,Cyriac Kandoth,David J. Dooling,Robert S. Fulton,Lucinda Fulton,Joelle Kalicki-Veizer,Michael D. McLellan,Michelle O'Laughlin,Heather Schmidt,Richard K. Wilson,Kai Ye,Ding Li,Adrian Ally,Miruna Balasundaram,Inanc Birol,Yaron S.N. Butterfield,Rebecca Carlsen,Candace Carter,Andy Chu,Eric Chuah,Hye Jung E. Chun,Noreen Dhalla,Ranabir Guin,Carrie Hirst,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Patrick Plettner,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Richard Varhol,A. Gordon Robertson,Andrew D. Cherniack,Itai Pashtan,Gordon Saksena,Robert C. Onofrio,Steven E. Schumacher,Barbara Tabak,Scott L. Carter,Bryan Hernandez,Jeff Gentry,Helga B. Salvesen,Helga B. Salvesen,Kristin G. Ardlie,Wendy Winckler,Rameen Beroukhim,Rameen Beroukhim,Matthew Meyerson,Angela Hadjipanayis,Semin Lee,Harshad S. Mahadeshwar,Peter J. Park,Alexei Protopopov,Xiaojia Ren,Sahil Seth,Xingzhi Song,Jiabin Tang,Ruibin Xi,Lixing Yang,Zeng Dong,Raju Kucherlapati,Lynda Chin,Lynda Chin,Jianhua Zhang,Jianhua Zhang,J. Todd Auman,Saianand Balu,Tom Bodenheimer,Elizabeth Buda,D. Neil Hayes,Alan P. Hoyle,Stuart R. Jefferys,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Lisle E. Mose,Joel S. Parker,Charles M. Perou,Jeff Roach,Shi Yan,Janae V. Simons,Mathew G. Soloway,Donghui Tan,Michael D. Topal,Scot Waring,Junyuan Wu,Katherine A. Hoadley,Stephen B. Baylin,Moiz S. Bootwalla,Phillip H. Lai,Timothy J. Triche,David Van Den Berg,Daniel J. Weisenberger,Peter W. Laird,Hui Shen,Hui Shen,Hui Shen,Juok Cho,Daniel DiCara,Scott Frazer,David I. Heiman,Rui Jing,Pei Lin,Will Mallard,Petar Stojanov,Doug Voet,Hailei Zhang,Lihua Zou,Michael S. Noble,Sheila Reynolds,Ilya Shmulevich,B. Arman Aksoy,Yevgeniy Antipin,Giovanni Ciriello,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,Marc Ladanyi,Boris Reva,Chris Sander,Rileen Sinha,S. Onur Sumer,Barry S. Taylor,Ethan Cerami,Nils Weinhold,Nikolaus Schultz,Ronglai Shen,Stephen C. Benz,Theodore C. Goldstein,David Haussler,Sam Ng,Christopher Szeto,Joshua M. Stuart,Christopher C. Benz,Christina Yau,Wei Zhang,Matti Annala,Matti Annala,Bradley M. Broom,Tod D. Casasent,Zhenlin Ju,Han Liang,Guoyan Liu,Yiling Lu,Anna K. Unruh,Chris Wakefield,John N. Weinstein,Nianxiang Zhang,Yuexin Liu,Russell Broaddus,Rehan Akbani,Gordon B. Mills,Christopher Adams,Thomas Barr,Aaron D. Black,Jay Bowen,John Deardurff,Jessica Frick,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Thomas Grossman,Hollie A. Harper,Melissa Hart-Kothari,Carmen Helsel,Aaron Hobensack,Harkness Kuck,Kelley Kneile,Kristen M. Leraas,Tara M. Lichtenberg,Cynthia McAllister,Robert E. Pyatt,Nilsa C. Ramirez,Nilsa C. Ramirez,Teresa R. Tabler,Nathan Vanhoose,Peter White,Lisa Wise,Erik Zmuda,Nandita Barnabas,Charlenia Berry-Green,Victoria Blanc,Lori Boice,Michael Button,Adam M. Farkas,Alexander A. Green,Jean MacKenzie,Dana Nicholson,Steve E. Kalloger,C. Blake Gilks,Beth Y. Karlan,Jenny Lester,Sandra Orsulic,Mark E. Borowsky,Mark G. Cadungog,Christine Czerwinski,Lori Huelsenbeck-Dill,Mary Iacocca,Nicholas J. Petrelli,Brenda Rabeno,Gary Witkin,Elena Nemirovich-Danchenko,Olga Potapova,D L Rotin,Andrew Berchuck,Michael J. Birrer,P.J. DiSaia,Laura Monovich,Erin Curley,Johanna Gardner,David Mallery,Robert Penny,Sean C. Dowdy,Boris Winterhoff,Linda Dao,Bobbie S. Gostout,Alexandra Meuter,Attila Teoman,Fanny Dao,Narciso Olvera,Faina Bogomolniy,Karuna Garg,Robert A. Soslow,Mikhail Abramov,John M. S. Bartlett,Sugy Kodeeswaran,Jeremy Parfitt,Fedor Moiseenko,Blaise A. Clarke,Marc T. Goodman,Michael E. Carney,Rayna K. Matsuno,Jennifer O. Fisher,Mei Huang,W. Kimryn Rathmell,Leigh B. Thorne,Linda Van Le,Rajiv Dhir,Robert Edwards,Esther Elishaev,Kristin K. Zorn,Paul J. Goodfellow,Paul J. Goodfellow,Paul J. Goodfellow,David G. Mutch,Ari B. Kahn,Daphne W. Bell,Pamela M. Pollock,Chen Wang,David A. Wheeler,Eve Shinbrot,Li Ding,Elaine R. Mardis,Brenda Ayala,Anna L. Chu,Mark A. Jensen,Prachi Kothiyal,Todd Pihl,Joan Pontius,David Pot,Eric E. Snyder,Deepak Srinivasan,Kenna R. Mills Shaw,Margi Sheth,Tanja Davidsen,Greg Eley,Martin L. Ferguson,Liming Yang,Mark S. Guyer,Bradley A. Ozenberger,Heidi J. Sofia,Douglas A. Levine +283 more
TL;DR: In this paper, the authors performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array-and-sequencing-based technologies, and classified them into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy number high.
Integrated genomic characterization of endometrial carcinoma
Gad Getz,Stacey Gabriel,Kristian Cibulskis,Eric S. Lander,Andrey Sivachenko,Carrie Sougnez,Michael S. Lawrence,Cyriac Kandoth,David J. Dooling,Robert S. Fulton,Lucinda Fulton,Joelle Kalicki-Veizer,Michael D. McLellan,Michelle O'Laughlin,Heather Schmidt,Richard K. Wilson,Kai Ye,Li Ding,Elaine R. Mardis,Adrian Ally,Miruna Balasundaram,Inanc Birol,Yaron S. Butterfield,Rebecca Carlsen,Candace D. Carter,Andy Chu,Eric Chuah,Hye Jung E. Chun,Noreen Dhalla,Ranabir Guin,Carrie Hirst,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Patrick Plettner,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Richard Varhol,A. Gordon Robertson,Andrew D. Cherniack,Itai Pashtan,Gordon Saksena,Robert C. Onofrio,Steven E. Schumacher,Barbara Tabak,Scott L. Carter,Bryan Hernandez,Jeff Gentry,Helga B. Salvesen,Kristin Ardlie,Wendy Winckler,Rameen Beroukhim,Matthew Meyerson,Angela Hadjipanayis,Semin Lee,Harshad S. Mahadeshwar,Peter J. Park,Alexei Protopopov,Xiaojia Ren,Sahil Seth,Xingzhi Song,Jiabin Tang,Ruibin Xi,Lixing Yang,Dong Zeng,Raju Kucherlapati,Lynda Chin,Jianhua Zhang,J. Todd Auman,Saianand Balu,Tom Bodenheimer,Elizabeth Buda,D. Neil Hayes,Alan P. Hoyle,Stuart R. Jefferys,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Lisle E. Mose,Joel S. Parker,Charles M. Perou,Jeff Roach,Yan Shi,Janae V. Simons,Mathew G. Soloway,Donghui Tan,Michael D. Topal,Scot Waring,Junyuan Wu,Katherine A. Hoadley,Stephen B. Baylin,Moiz S. Bootwalla,Phillip H. Lai,Timothy J. Triche,David Van Den Berg,Daniel J. Weisenberger,Peter W. Laird,Hui Shen,Juok Cho,Daniel DiCara,Scott Frazer,David I. Heiman,Rui Jing,Pei Lin,Will Mallard,Petar Stojanov,Doug Voet,Hailei Zhang,Lihua Zou,Michael S. Noble,Sheila M. Reynolds,Ilya Shmulevich,B. Arman Aksoy,Yevgeniy Antipin,Giovanni Ciriello,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,Marc Ladanyi,Boris Reva,Chris Sander,Rileen Sinha,S. Onur Sumer,Barry S. Taylor,Ethan Cerami,Nils Weinhold,Nikolaus Schultz,Ronglai Shen,Stephen C. Benz,Theodore C. Goldstein,David Haussler,Sam Ng,Christopher Szeto,Joshua M. Stuart,Christopher C. Benz,Christina Yau,Wei Zhang,Matti Annala,Bradley M. Broom,Tod D. Casasent,Zhenlin Ju,Han Liang,Guoyan Liu,Yiling Lu,Anna K. Unruh,Chris Wakefield,John N. Weinstein,Nianxiang Zhang,Yuexin Liu,Russell Broaddus,Rehan Akbani,Gordon B. Mills,Christopher Adams,Thomas Barr,Aaron D. Black,Jay Bowen,John Deardurff,Jessica Frick,Julie M. Gastier-Foster,Thomas Grossman,Hollie A. Harper,Melissa Hart-Kothari,Carmen Helsel,Aaron Hobensack,Harkness Kuck,Kelley Kneile,Kristen M. Leraas,Tara M. Lichtenberg,Cynthia McAllister,Robert E. Pyatt,Nilsa C. Ramirez,Teresa R. Tabler,Nathan Vanhoose,Peter White,Lisa Wise,Erik Zmuda,Nandita Barnabas,Charlenia Berry-Green,Victoria Blanc,Lori Boice,Michael Button,Adam M. Farkas,Alexander A. Green,Jean MacKenzie,Dana Nicholson,Steve E. Kalloger,C Blake Gilks,Beth Y. Karlan,Jenny Lester,Sandra Orsulic,Mark L. Borowsky,Mark G. Cadungog,Christine Czerwinski,Lori Huelsenbeck-Dill,Mary Iacocca,Nicholas J. Petrelli,Brenda Rabeno,Gary Witkin,Elena Nemirovich-Danchenko,Olga Potapova,D L Rotin,Andrew Berchuck,Michael J. Birrer,P.J. DiSaia,Laura Monovich,Erin Curley,Johanna Gardner,David Mallery,Robert Penny,Sean C. Dowdy,Boris Winterhoff,Linda Dao,Bobbie S. Gostout,Alexandra Meuter,Attila Teoman,Fanny Dao,Narciso Olvera,Faina Bogomolniy,Karuna Garg,Robert A. Soslow,Douglas A. Levine,Mikhail Abramov,John M. S. Bartlett,Sugy Kodeeswaran,Jeremy Parfitt,Fedor Moiseenko,Blaise A. Clarke,Marc T. Goodman,Michael E. Carney,Rayna K. Matsuno,Jennifer C. Fisher,Mei Huang,W. Kimryn Rathmell,Leigh B. Thorne,Linda Van Le,Rajiv Dhir,Robert R. Edwards,Esther Elishaev,Kristin K. Zorn,Paul J. Goodfellow,David G. Mutch,Ari B. Kahn,Daphne W. Bell,Pamela M. Pollock,Chen Wang,David A. Wheeler,Eve Shinbrot,Brenda Ayala,Anna L. Chu,Mark A. Jensen,Prachi Kothiyal,Todd Pihl,Joan Pontius,David A. Pot,Eric E. Snyder,Deepak Srinivasan,Kenna R. Mills Shaw,Margi Sheth,Tanja Davidsen,Greg Eley Martin L. Ferguson,John A. Demchok,Liming Yang,Mark S. Guyer,Bradley A. Ozenberger,Heidi J. Sofia +271 more
TL;DR: The genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours, and these features are classified into four categories: POLE ultramutated, microsatellite instability hypermutated, copy- number low, and copy-number high.
Journal ArticleDOI
Oncogenic pathway signatures in human cancers as a guide to targeted therapies.
Andrea Bild,Guang Yao,Jeffrey T. Chang,Quanli Wang,Anil Potti,Dawn Chasse,Mary Beth Joshi,David H. Harpole,Johnathan M. Lancaster,Andrew Berchuck,John A. Olson,Jeffrey R. Marks,Holly K. Dressman,Mike West,Joseph R. Nevins +14 more
TL;DR: It is shown that gene expression signatures can be identified that reflect the activation status of several oncogenic pathways and linked with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogens pathway signatures to guide the use of targeted therapeutics.