J
Jeffrey G. Lawrence
Researcher at University of Pittsburgh
Publications - 74
Citations - 15096
Jeffrey G. Lawrence is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 44, co-authored 74 publications receiving 14367 citations. Previous affiliations of Jeffrey G. Lawrence include Washington University in St. Louis & University of Utah.
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Journal ArticleDOI
Lateral gene transfer and the nature of bacterial innovation
TL;DR: Unlike eukaryotes, which evolve principally through the modification of existing genetic information, bacteria have obtained a significant proportion of their genetic diversity through the acquisition of sequences from distantly related organisms.
Journal ArticleDOI
Re-evaluating prokaryotic species
Dirk Gevers,Frederick M. Cohan,Jeffrey G. Lawrence,Brian G. Spratt,Tom Coenye,Edward J. Feil,Erko Stackebrandt,Yves Van de Peer,Peter Vandamme,Fabiano L. Thompson,Jean Swings +10 more
TL;DR: The current and future impact of multilocus nucleotide-sequence-based approaches to prokaryotic systematics are discussed and the potential, and difficulties, of assigning species status to biologically or ecologically meaningful sequence clusters are considered.
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Molecular archaeology of the Escherichia coli genome
TL;DR: It is found that 755 of 4,288 ORFs have been introduced into the E. coli genome in at least 234 lateral transfer events since this species diverged from the Salmonella lineage 100 million years ago.
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Prokaryotic Evolution in Light of Gene Transfer
TL;DR: The role of recombination and HGT in giving phenotypic "coherence" to prokaryotic taxa at all levels of inclusiveness, the implications of these processes for the reconstruction and meaning of "phylogeny," and new views of proKaryotic adaptation and diversification based on gene acquisition and exchange are discussed.
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Amelioration of Bacterial Genomes: Rates of Change and Exchange
TL;DR: Estimates of amelioration times indicate that the entire Escherichia coli chromosome contains more than 600 kb of horizontally transferred, protein-coding DNA, which predicts that the E. coli and Salmonella enterica lineages have each gained and lost more than 3 megabases of novel DNA since their divergence.