Jeffrey L. Goldberg

TL;DR: The cloning and characterization of ephexin is reported, a novel Eph receptor-interacting protein that is a member of the Dbl family of guanine nucleotide exchange factors for Rho GTPases that provides a novel mechanism for achieving highly localized regulation of growth cone motility.

TL;DR: In this paper, a method for promoting CNS axon regeneration was proposed, comprising of inhibiting the expression or activity in a neuron of one or more of the members of the Kruppel-like transcription factor (KLF) family that suppress axon growth (e.g., KLF 1, 2, 3, 4, 5, 6, 9, 12, 13, 14, 15 and/or 16), and stimulating the expression and activity of neurons of the KLF family that promote axon expansion.

TL;DR: It is shown that amacrine cells signal neonatal rat retinal ganglion cells (RGCs) to undergo a profound and apparently irreversible loss of intrinsic axon growth ability, and retinal maturation triggers RGCs to greatly increase their dendritic growth ability.

TL;DR: It is shown that bcl-2 overexpression is sufficient to keep purified RGCs alive in the absence of any glial or trophic support and provides insight into the signals that may be necessary to promote CNS regeneration.

TL;DR: Recent studies concerning the nature of the signals necessary to promote neuronal survival and growth are reviewed, with an emphasis on their significance to regeneration after CNS injury.