M
Michael Z. Lin
Researcher at Stanford University
Publications - 107
Citations - 20239
Michael Z. Lin is an academic researcher from Stanford University. The author has contributed to research in topics: Calcium imaging & Bioluminescence. The author has an hindex of 48, co-authored 100 publications receiving 17867 citations. Previous affiliations of Michael Z. Lin include University of California, Los Angeles & Harvard University.
Papers
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Journal ArticleDOI
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
TL;DR: It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene.
Journal ArticleDOI
Improving the photostability of bright monomeric orange and red fluorescent proteins.
Nathan C. Shaner,Michael Z. Lin,Michael R. McKeown,Paul Steinbach,Kristin L. Hazelwood,Michael W. Davidson,Roger Y. Tsien +6 more
TL;DR: This work developed highly photostable variants of mOrange and TagRFP that maintain most of the beneficial qualities of the original proteins and perform as reliably as Aequorea victoria GFP derivatives in fusion constructs.
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Neurogenin Promotes Neurogenesis and Inhibits Glial Differentiation by Independent Mechanisms
Yi Sun,Mireya Nadal-Vicens,Stephanie Misono,Michael Z. Lin,Ana M. Zubiaga,Xianxing Hua,Guoping Fan,Michael E. Greenberg +7 more
TL;DR: It is found that in addition to inducing neurogenesis, the bHLH transcription factor neurogenin (Ngn1) inhibits the differentiation of neural stem cells into astrocytes.
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Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics
TL;DR: Point mutation of Ile(170) of ChEF to Val (yielding "ChIEF") accelerates the rate of channel closure while retaining reduced inactivation, leading to more consistent responses when stimulated above 25 Hz in both HEK293 cells and cultured hippocampal neurons.
Journal ArticleDOI
EphB receptors interact with NMDA receptors and regulate excitatory synapse formation.
Matthew B. Dalva,Mari A. Takasu,Michael Z. Lin,Steven M. Shamah,Linda Hu,Nicholas W. Gale,Michael E. Greenberg +6 more
TL;DR: EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function, and EphrinB activation of EphB promotes an association of E phB with NMDA receptors that may be critical for synapse development or function.