Jeffrey M. Leiden

TL;DR: A signaling pathway initiated by eIF2alpha phosphorylation protects cells against metabolic consequences of ER oxidation by promoting the linked processes of amino acid sufficiency and resistance to oxidative stress.

TL;DR: Analysis of cardiac development in the GATA4-/- mice demonstrated that these embryos developed splanchnic mesoderm, which differentiated into primitive cardiac myocytes that expressed contractile proteins that formed aberrant cardiac structures in the anterior and dorsolateral regions of the embryo.

TL;DR: It is shown that CD28 stimulation augments T- cell immune responses by specifically inducing a 5- to 50-fold enhancement in the expression and secretion of interleukin 2, tumor necrosis factor type alpha, lymphotoxin, interferon gamma, and granulocyte-macrophage colony-stimulating factor in normal human T cells stimulated to proliferate by crosslinking of the T-cell receptor/CD3 complex.

TL;DR: It is demonstrated that immune responses directed against foreign transgene–encoded proteins are the major determinants of the stability of gene expression following i.m. injection of RDAd.

TL;DR: The results show that GATA-3−/− ES cells can contribute to the development of the mature ery-throid, myelomonocytic and B-cell lineages, but fail to give rise to thymocytes or mature peripheral T cells, suggesting that Gata-3 is an essential and specific regulator of early thymocyte development.