Jeffrey M. Sequeira

TL;DR: Serum from 25 of the 28 patients and 0 of 28 control subjects contained high-affinity blocking autoantibodies against membrane-bound folate receptors that are present on the choroid plexus, which normalized 5MTHF levels in the cerebrospinal fluid and led to clinical improvement.

TL;DR: It is hypothesized that autoantibodies against folate receptors in women may be associated with pregnancy complicated by a neural-tube defect, and serum from 12 women who were or had been pregnant with a fetus with a Neural-Tube defect was analyzed.

TL;DR: It is suggested that FRAs may be important in ASD and that FRA-positive children with ASD may benefit from leucovorin calcium treatment, and additional studies of folate receptor autoimmunity and leucovsky calcium treatment in children with ASDs are warranted.

TL;DR: Serum FR autoimmunity appears to represent an important factor in the pathogenesis of reduced folate transport to the nervous system among children with early-onset low-functioning autism associated with or without neurological deficits.

TL;DR: Tryptic digest of the protein extracted from a sodium dodecyl sulfate-polyacrylamide gel electrophoresis gel and subjected to liquid chromatography/mass spectrometry identified 4 peptides that matched with a membrane protein in the data bank.