S
Sheldon P. Rothenberg
Researcher at United States Department of Veterans Affairs
Publications - 25
Citations - 668
Sheldon P. Rothenberg is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Dihydrofolate reductase & Receptor. The author has an hindex of 11, co-authored 25 publications receiving 655 citations. Previous affiliations of Sheldon P. Rothenberg include SUNY Downstate Medical Center & Roche Institute of Molecular Biology.
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Journal ArticleDOI
Autoantibodies against Folate Receptors in Women with a Pregnancy Complicated by a Neural-Tube Defect
Sheldon P. Rothenberg,Maria da Costa,Jeffrey M. Sequeira,Joan Cracco,Jaclyn L. Roberts,Jeremy Weedon,Edward V. Quadros +6 more
TL;DR: It is hypothesized that autoantibodies against folate receptors in women may be associated with pregnancy complicated by a neural-tube defect, and serum from 12 women who were or had been pregnant with a fetus with a Neural-Tube defect was analyzed.
Journal ArticleDOI
Autoantibodies Against Folate Receptors in Women With a Pregnancy Complicated by a Neural Tube Defect
Sheldon P. Rothenberg,Maria da Costa,Jeffrey M. Sequeira,Joan Cracco,Jaclyn L. Roberts,Jeremy Weedon,Edward V. Quadros +6 more
TL;DR: Serum from women with a pregnancy complicated by a neural-tube defect contains autoantibodies that bind to folate receptors and can block the cellular uptake of folate.
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Purification, properties, and immunological characterization of folate-binding proteins from human leukemia cells.
Easwara Sadasivan,Easwara Sadasivan,Easwara Sadasivan,Maria da Costa,Maria da Costa,Maria da Costa,Sheldon P. Rothenberg,Sheldon P. Rothenberg,Sheldon P. Rothenberg,Larry Brink,Larry Brink,Larry Brink +11 more
TL;DR: A new matrix for affinity chromatography using pteroylglutamic acid coupled to an epoxy-activated matrix via hexanediamine resulted in negligible ligand leakage and permitted the purification of soluble and membrane-associated folate-binding proteins from human leukemia cells contained in a human spleen.
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Transfection of a glycosylated phosphatidylinositol-anchored folate-binding protein complementary DNA provides cells with the ability to survive in low folate medium.
Carol Luhrs,Curtis A. Raskin,Russell K. Durbin,Biyun Wu,Easwara Sadasivan,William T. McAllister,Sheldon P. Rothenberg +6 more
TL;DR: The results of these experiments indicate that the GPI-anchored folate-binding protein provides a mechanism to maintain a level of folate that permits the folatespine-dependent metabolic functions necessary for cell survival under low folate conditions.
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Identification of a 4-base deletion in the gene in inherited intrinsic factor deficiency.
Fawwaz Yassin,Sheldon P. Rothenberg,Sreedhar P. Rao,Marilyn M. Gordon,David H. Alpers,Edward V. Quadros +5 more
TL;DR: A 4-base deletion has been identified in the coding region of the gene for gastric intrinsic factor (IF) in an 11-year-old girl with severe anemia and cobalamin deficiency and introduces a site for BsaBI for identifying this deletion in hereditary IF deficiency.