J
Jeffrey P. Bond
Researcher at Boston Children's Hospital
Publications - 63
Citations - 3695
Jeffrey P. Bond is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: DNA glycosylase & Gene. The author has an hindex of 29, co-authored 63 publications receiving 3399 citations. Previous affiliations of Jeffrey P. Bond include University of Vermont.
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The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
Oliver Dienz,Sheri M. Eaton,Jeffrey P. Bond,Wendy A. Neveu,David Moquin,Rajkumar Noubade,Eva M. Briso,Colette Charland,Warren J. Leonard,Gennaro Ciliberto,Cory Teuscher,Laura Haynes,Mercedes Rincon +12 more
TL;DR: It is shown that IL-6 is sufficient and necessary to induce IL-21 production by naive and memory CD4+ T cells upon T cell receptor stimulation and could be a potential coadjuvant to enhance humoral immunity.
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A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII
TL;DR: Three new putative human DNA glycosylases are identified that are phylogenetically members of the Fpg/Nei family primarily found in the bacterial kingdom, and one is characterized, hNEI1, and shown to be functionally homologous to bacterial Nei.
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Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer
Theresa Casey,Theresa Casey,Jeffrey P. Bond,Scott Tighe,T. C. Hunter,Laura Lintault,Osman V. Patel,Jonathan D. Eneman,Abigail Crocker,Jeffrey H. White,Joseph Tessitore,Mary A. Stanley,Seth P. Harlow,Donald L. Weaver,Hyman B. Muss,Karen Plaut +15 more
TL;DR: A mechanistic model that spurs invasion is proposed, that shows breast cancer invasion proceeds through the acquisition of a motile phenotype in tumor epithelial cells and a reactive phenotype in cancer associated fibroblasts.
Journal Article
TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution.
TL;DR: It is shown that somatic TP53 abnormalities are more common in breast cancer associated with BRCA1 or BRCa2 germ-line mutations than in sporadic breast cancers, and the results suggest that BRC a1/2 mutations influence the type and distribution of TP53 mutations seen in breast cancers.
Journal ArticleDOI
Evolutionary conservation and somatic mutation hotspot maps of p53 : correlation with p53 protein structural and functional features
D R Walker,Jeffrey P. Bond,R E Tarone,Chris Harris,Wojciech Makalowski,Mark S. Boguski,Marc S. Greenblatt +6 more
TL;DR: The results indicate that targeting highly conserved regions for mutational and functional analysis may be efficient strategies for the study of cancer-related genes.